Academic Journal
Engineering Solutions for Representative Models of the Gastrointestinal Human-Microbe Interface
| العنوان: | Engineering Solutions for Representative Models of the Gastrointestinal Human-Microbe Interface |
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| المؤلفون: | Mac Giolla Eain, Marc, Baginska, Joanna, Greenhalgh, Kacy, Fritz, Joëlle, Zenhausern, Frederic, Wilmes, Paul |
| المصدر: | Engineering (2017) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2017 |
| المجموعة: | University of Luxembourg: ORBilu - Open Repository and Bibliography |
| مصطلحات موضوعية: | Microbiome, Microfluidics, Organ-on-a-chip, HuMiX, Engineering, computing & technology, Ingénierie, informatique & technologie |
| الوصف: | peer reviewed ; Host-microbe interactions at the gastrointestinal interface have emerged as a key component in the governance of human health and disease. Advances in micro-physiological systems are providing researchers with unprecedented access and insights into this complex relationship. These systems combine the benefits of microengineering, microfluidics, and cell culture in a bid to recreate the environmental conditions prevalent in the human gut. Here we present the human-microbial cross talk (HuMiX) platform, one such system that leverages this multidisciplinary approach to provide a representative in vitro model of the human gastrointestinal interface. HuMiX presents a novel and robust means to study the molecular interactions at the host-microbe interface. We summarize our proof-of-concept results obtained using the platform and highlight its potential to greatly enhance our understanding of host-microbe interactions with a potential to greatly impact the pharmaceutical, food, nutrition, and healthcare industries in the future. A number of key questions and challenges facing these technologies are also discussed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2095-8099 |
| Relation: | FNR11014639 - A Microfluidics-based Drug Discovery Platform Emulating The Human Microbiome On Chip, 2015 (01/01/2016-30/04/2017) - Paul Wilmes; urn:issn:2095-8099; https://orbilu.uni.lu/handle/10993/38652; info:hdl:10993/38652; https://orbilu.uni.lu/bitstream/10993/38652/1/GiollaEain%282017%29Engineering.pdf; wos:000398040300008 |
| DOI: | 10.1016/J.ENG.2017.01.011 |
| الاتاحة: | https://orbilu.uni.lu/handle/10993/38652 https://orbilu.uni.lu/bitstream/10993/38652/1/GiollaEain%282017%29Engineering.pdf https://doi.org/10.1016/J.ENG.2017.01.011 |
| Rights: | open access ; http://purl.org/coar/access_right/c_abf2 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.44A3DDB1 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20958099 |
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| DOI: | 10.1016/J.ENG.2017.01.011 |