Academic Journal
SARS‐CoV‐2 and omicron variant detection with a high selectivity, sensitivity, and low‐cost silicon bio‐nanosensor
| العنوان: | SARS‐CoV‐2 and omicron variant detection with a high selectivity, sensitivity, and low‐cost silicon bio‐nanosensor |
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| المؤلفون: | Leonardi, Antonio Alessio, Sciuto, Emanuele Luigi, Lo Faro, Maria José, Fazio, Barbara, Rizzo, Maria Giovanna, Calabrese, Giovanna, Francioso, Luca, Picca, Rosaria, Nastasi, Francesco, Mancuso, Giuseppe, Spinella, Corrado, Knoll, Wolfgang, Irrera, Alessia, Conoci, Sabrina |
| المصدر: | Nano Select ; volume 4, issue 2, page 160-169 ; ISSN 2688-4011 2688-4011 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | The recent SARS‐CoV‐2 pandemic has highlighted the urgent need for novel point‐of‐care devices to be promptly used for a rapid and reliable large screening analysis of several biomarkers like genetic sequences and antibodies. Currently, one of the main limitations of rapid tests is the high percentage of false negatives in the presence of variants and, in particular for the Omicron one. We demonstrate in this work the detection of SARS‐CoV‐2 and the Omicron variant with a cost‐effective silicon nanosensor enabling high sensitivity, selectivity, and fast response. We have shown that a silicon (Si) nanowires (NW) platform detects both Sars‐CoV‐2 and its Omicron variant with a limit of detection (LoD) of four effective copies (cps), without any amplification of the genome, and with high selectivity. This ultrasensitive detection of 4 cps allows to obtain an extremely early diagnosis paving the way for efficient and widespread tracking. The sensor is made with industrially compatible techniques, which in perspective may allow easy and cost‐effective industrialization. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/nano.202200188 |
| الاتاحة: | http://dx.doi.org/10.1002/nano.202200188 https://onlinelibrary.wiley.com/doi/pdf/10.1002/nano.202200188 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/nano.202200188 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.44A2FFEE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/nano.202200188 |
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