التفاصيل البيبلوغرافية
| العنوان: |
High KEAP1, NRF2 and Low HO-1 Serum Levels in Children with Autism |
| المؤلفون: |
AYAYDIN, Hamza, AKALTUN, İsmail, KOYUNCU, İsmail, ÇELİK, Hakim, KİRMİT, Adnan, TAKATAK, Hatice |
| المصدر: |
Noro Psikiyatr Ars |
| بيانات النشر: |
Noro-Psikiyatri Arsivi |
| سنة النشر: |
2020 |
| مصطلحات موضوعية: |
Research Article, psy, socio |
| الوصف: |
INTRODUCTION: The purpose of our study was to investigate heme oxygenase-1 (HO-1), nuclear factor erythroid-2-related factor 2 (NRF2), and kelch-like ECH-associated protein 1 (KEAP1) levels in children with autism spectrum disorder (ASD) and to reveal their association with the severity of autism. METHODS: This study measured serum HO-1, KEAP1, and NRF2 levels in 43 patients with ASD (aged 3–12 years) and in 41 age– and gender-matched healthy controls. ASD severity was rated using the Childhood Autism Rating Scale (CARS). HO-1, KEAP1, and NRF2 levels were determined in the biochemistry laboratory using the ELISA technique. RESULTS: HO-1 levels were significantly lower in patients aged 3–12 years compared to controls aged 3–12, while KEAP1 and NRF2 levels were significantly higher (p=0.020, p0.05). CONCLUSION: This study suggests that oxidative stress is higher in children with ASD and that HO-1 levels are insufficient to achieve oxidative balance. |
| نوع الوثيقة: |
text |
| اللغة: |
English |
| Relation: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735139/ |
| الاتاحة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735139/ |
| Rights: |
undefined |
| رقم الانضمام: |
edsbas.44A2C5C2 |
| قاعدة البيانات: |
BASE |