Academic Journal
Detection and outcome of occult leptomeningeal disease in diffuse large B-cell lymphoma and Burkitt lymphoma
| العنوان: | Detection and outcome of occult leptomeningeal disease in diffuse large B-cell lymphoma and Burkitt lymphoma |
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| المؤلفون: | Wilson, WH, Bromberg, Jacoline, Stetler-Stevenson, M, Steinberg, SM, Martin-Martin, L, Muniz, C, Sancho, JM, Caballero, MD, Davidis, MA, Brooimans, Rik, Sanchez-Gonzalez, B, Salar, A, Gonzalez-Barca, E, Ribera, JM, Shovlin, M, Filie, A, Dunleavy, K, Mehrling, T, Spina, M, Orfao, A |
| المصدر: | Wilson , WH , Bromberg , J , Stetler-Stevenson , M , Steinberg , SM , Martin-Martin , L , Muniz , C , Sancho , JM , Caballero , MD , Davidis , MA , Brooimans , R , Sanchez-Gonzalez , B , Salar , A , Gonzalez-Barca , E , Ribera , JM , Shovlin , M , Filie , A , Dunleavy , K , Mehrling , T , Spina , M & Orfao , A 2014 , ' Detection and outcome of occult leptomeningeal disease in diffuse large B-cell lymphoma and Burkitt lymphoma ' , .... |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | /dk/atira/pure/keywords/researchprograms/AFL001000/EMCMM027203, name=EMC MM-02-72-03, /dk/atira/pure/keywords/researchprograms/AFL001000/EMCMM034406, name=EMC MM-03-44-06 |
| الوصف: | The benefit of intrathecal therapy and systemic rituximab on the outcome of diffuse large B-cell lymphoma at risk of central nervous system disease is controversial. Furthermore, the effect of intrathecal treatment and rituximab in diffuse large B-cell and Burkitt lymphoma with occult leptomeningeal disease detected by flow cytometry at diagnosis is unknown. Untreated diffuse large B-cell (n=246) and Burkitt (n=80) lymphoma at clinical risk of central nervous system disease and having had pre-treatment cerebrospinal fluid were analyzed by flow cytometry and cytology. Spinal fluid involvement was detected by flow cytometry alone (occult) in 33 (13%) diffuse large B-cell and 9 (11%) Burkitt lymphoma patients, and detected by cytology in 11 (4.5%) and 5 (6%) patients, respectively. Diffuse large B-cell lymphoma with occult spinal fluid involvement had poorer survival (P=0.0001) and freedom from central nervous system relapse (P<0.0001) compared to negative cases. Burkitt lymphoma with occult spinal fluid involvement had an inferior freedom from central nervous system relapse (P=0.026) but not survival. The amount of intrathecal chemotherapy was quantitatively associated with survival in diffuse large B-cell lymphoma with (P=0.02) and without (P=0.001) occult spinal fluid involvement. However, progression of systemic disease and not control of central nervous system disease was the principal cause of treatment failure. In diffuse large B-cell lymphoma, systemic rituximab was associated with improved freedom from central nervous system relapse (P=0.003) but not with survival. Our results suggest that patients at risk of central nervous system disease should be evaluated by flow cytometry and that intrathecal prophylaxis/therapy is beneficial. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3324/haematol.2013.101741 |
| الاتاحة: | https://pure.eur.nl/en/publications/c1cd3957-1f82-4143-8ab4-22765b6a52f3 https://doi.org/10.3324/haematol.2013.101741 http://hdl.handle.net/1765/60243 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.449EC839 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3324/haematol.2013.101741 |
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