Academic Journal
Immunology of leishmaniasis
| العنوان: | Immunology of leishmaniasis |
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| المؤلفون: | Gicheru, M. M., Mutiso, J. M., Macharia, J. C., Ozwara, H. |
| سنة النشر: | 2013 |
| المجموعة: | Kenyatta University Repository |
| مصطلحات موضوعية: | Leishmaniasis, Murine, Human, Immune response |
| الوصف: | Resolution of leishmanial infection is dependent on the coordinated interactions between components of cell mediated immune response, central to which is the activation of targeted T-cell populations for appropriate cytokine production and activation of infected cells. In human as well as murine leishmaniasis, cure is associated with predominant Th1 response, good cell-mediated immunity (CMI), production of interferon gamma (IFN-γ) and macrophage activation. On the other hand, cytokine analysis in visceral leishmaniasis reveals enhanced induction of IL-10 and⁄or IL-4 mRNA in tissues, poor CMI, hypergammaglobulinaemia and enhanced presence of IL-4 in circulation of patients with progressive disease. The Th1/Th2 paradigm of resistance/susceptibility is an oversimplication ofa far more complicated network of regulatory/counter-regulatory interactions and thus a deficit in the understanding of the exact mechanisms involved in resolution vs severity of leishmaniasis. This review, in additionto giving a general overview of basic immunology of Leishmania infection, consolidates findings on immune responses in experimental and human leishmaniasis. Such information is important in giving a feasible direction in designing prophylactic and therapeutic strategies against leishmaniasis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1582-1366 |
| Relation: | Scientia Parasitologica 14(2):51-61, June 2013; http://oris.nacosti.go.ke/modules/library/publications/research_reports/NACOSTI-DL-RR-1017.pdf; http://ir-library.ku.ac.ke/handle/123456789/10274 |
| الاتاحة: | http://ir-library.ku.ac.ke/handle/123456789/10274 http://oris.nacosti.go.ke/modules/library/publications/research_reports/NACOSTI-DL-RR-1017.pdf |
| رقم الانضمام: | edsbas.444C6952 |
| قاعدة البيانات: | BASE |
| تدمد: | 15821366 |
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