Academic Journal
Molecular Signaling Involved in Oxysterol-Induced β1-Integrin
| العنوان: | Molecular Signaling Involved in Oxysterol-Induced β1-Integrin |
|---|---|
| المؤلفون: | Over-expression In Human Macrophages, Simona Gargiulo, Paola Gamba, Gabriella Testa, Barbara Sottero, Marco Maina, Tina Guina, Fiorella Biasi, Gabriella Leonarduzzi |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.mdpi.com/1422-0067/13/11/14278/pdf/. |
| سنة النشر: | 2012 |
| المجموعة: | CiteSeerX |
| الوصف: | The hypercholesterolemia-atherosclerosis association is now established; hypercholesterolemia may induce vascular-cell activation, subsequently increasing expression of adhesion molecules, cytokines, chemokines, growth factors, and other key inflammatory molecules. Among inflammatory molecules expressed by vascular cells, integrins play a critical role in regulating macrophage activation and migration to the site of inflammation, by mediating cell-cell and cell-extracellular matrix interactions. The main lipid oxidation products present in oxidized LDL that may be responsible for inflammatory processes in atherogenesis, are cholesterol oxidation products, known as oxysterols. This study demonstrates the effect of an oxysterol mixture, compatible with that detectable in human hypercholesterolemic plasma, on the expression and synthesis of β1-integrin in cells of the macrophage lineage. The molecular signaling whereby oxysterols induce β1-integrin up-regulation is also comprehensively investigated. Over-expression of β1-integrin depends on activation of classic and novel members of protein kinase C and extracellular signal-regulated kinases 1 and 2, as well as of the up-stream G-protein (Gq and G13), c-Src, and phospholipase C. In addition, the localization of β1-integrin in advanced human carotid |
| نوع الوثيقة: | text |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.407.7102; http://www.mdpi.com/1422-0067/13/11/14278/pdf/ |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.407.7102 http://www.mdpi.com/1422-0067/13/11/14278/pdf/ |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.4410E506 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |