Academic Journal
Longitudinal assessment of SARS-CoV-2 IgG seroconversionamong front-line healthcare workers during the first wave of the Covid-19 pandemic at a tertiary-care hospital in Chile
| العنوان: | Longitudinal assessment of SARS-CoV-2 IgG seroconversionamong front-line healthcare workers during the first wave of the Covid-19 pandemic at a tertiary-care hospital in Chile |
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| المؤلفون: | Iruretagoyena, Mirentxu, Vial, Macarena R., Spencer-Sandino, Maria, Gaete, Pablo, Peters, Anne, Delgado, Iris, Perez, Inia, Calderon, Claudia, Porte, Lorena, Legarraga, Paulette, Anderson, Alicia, Aguilera, Ximena, Vial, Pablo, Weitzel, Thomas, Munita, Jose M. |
| المصدر: | BMC Infectious Diseases ; volume 21, issue 1 ; ISSN 1471-2334 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2021 |
| الوصف: | Background Healthcare workers (HCWs) are at high risk of exposure to SARS-CoV-2. Cross-sectional studies have provided variable rates of seroprevalence in HCWs. Longitudinal assessments of the serological response to Covid-19 among HCWs are crucial to understanding the risk of infection and changes in antibody titers over time. We aimed to investigate seroprevalence and risk factors associated with seroconversion in a prospective cohort of HCWs during the peak of the first wave of the Covid-19 pandemic. Methods We conducted a longitudinal study among 446 front-line HCWsin a tertiary-care hospital in Chile from April to July 2020. IgG was determined monthly using two different ELISAs in serum samples of HCWs, during the three-month period. In each visit, demographic data, symptoms, risk factors, and exposure risks were also assessed. Results The overall seroprevalence at the end of the study period was 24% (95% CI20.2–28.3), with 43% of seropositive HCWs reporting no prior symptoms. Seroconversion rates significantly differed over the study period, from 2.1% to as high as 8.8% at the peak of the epidemic. There were no statistically significant differences observed between HCWs in direct clinical care of patients with Covid-19 and those working in low risk areas. Antibody titers appeared to wane over time. Conclusions HCWs were severely affected with a high rate of seroconversion that appeared to mirror the local epidemiological situation. A significant amount of participants underwent an asymptomatic infection, highlighting the need for improved surveillance policies. Antibody titers appear to wane over time; further studies to understand this finding’s impact on the risk of reinfection are warranted. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12879-021-06208-2 |
| DOI: | 10.1186/s12879-021-06208-2.pdf |
| DOI: | 10.1186/s12879-021-06208-2/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s12879-021-06208-2 https://link.springer.com/content/pdf/10.1186/s12879-021-06208-2.pdf https://link.springer.com/article/10.1186/s12879-021-06208-2/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.43B872D0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12879-021-06208-2 |
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