Academic Journal
The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting
| العنوان: | The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting |
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| المؤلفون: | Smit, Martine J., Schlecht-Louf, Géraldine, Neves, Maria, Van Den Bor, Jelle, Penela, Petronila, Siderius, Marco, Bachelerie, Françoise, Mayor, Federico |
| المصدر: | Smit , M J , Schlecht-Louf , G , Neves , M , Van Den Bor , J , Penela , P , Siderius , M , Bachelerie , F & Mayor , F 2021 , ' The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting ' , Annual Review of Pharmacology and Toxicology , vol. 61 , pp. 541-563 . https://doi.org/10.1146/annurev-pharmtox-010919-023340 |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | ACKR3, cancer, chemokine receptors, CXCR4, GPCRs, therapeutics, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being |
| الوصف: | Elevated expression of the chemokine receptors CXCR4 and ACKR3 and of their cognate ligand CXCL12 is detected in a wide range of tumors and the tumor microenvironment (TME). Yet, the molecular mechanisms by which the CXCL12/CXCR4/ACKR3 axis contributes to the pathogenesis are complex and not fully understood. To dissect the role of this axis in cancer, we discuss its ability to impinge on canonical and less conventional signaling networks in different cancer cell types; its bidirectional crosstalk, notably with receptor tyrosine kinase (RTK) and other factors present in the TME; and the infiltration of immune cells that supporttumor progression. We discuss current and emerging avenues that target the CXCL12/CXCR4/ACKR3 axis. Coordinately targeting both RTKs and CXCR4/ACKR3 and/or CXCL12 is an attractive approach to consider in multitargeted cancer therapies. In addition, inhibiting infiltrating immune cells or reactivating the immune system along with modulating the CXCL12/CXCR4/ACKR3 axis in the TME has therapeutic promise. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/grantAgreement/EC/H2020/860229 |
| DOI: | 10.1146/annurev-pharmtox-010919-023340 |
| الاتاحة: | https://research.vu.nl/en/publications/fcc7e6ee-25ce-4ea5-91e7-0bb0132b7d84 https://doi.org/10.1146/annurev-pharmtox-010919-023340 https://hdl.handle.net/1871.1/fcc7e6ee-25ce-4ea5-91e7-0bb0132b7d84 https://research.vu.nl/ws/files/225104992/The_CXCL12_CXCR4_ACKR3_Axis_in_the_Tumor_Microenvironment.pdf http://www.scopus.com/inward/record.url?scp=85097735831&partnerID=8YFLogxK http://www.scopus.com/inward/citedby.url?scp=85097735831&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.4378FE3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1146/annurev-pharmtox-010919-023340 |
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