Academic Journal
Synthesis and Pharmacological Evaluation of Novel 1′‐[2‐(Difluoromethoxy)benzyl]‐2′ H,5′ H‐spiro[8‐azabicyclo[3.2.1]octane‐3,4′‐imidazolidine]‐2′,5′‐diones and Their Derivatives
| العنوان: | Synthesis and Pharmacological Evaluation of Novel 1′‐[2‐(Difluoromethoxy)benzyl]‐2′ H,5′ H‐spiro[8‐azabicyclo[3.2.1]octane‐3,4′‐imidazolidine]‐2′,5′‐diones and Their Derivatives |
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| المؤلفون: | Madaiah, Malavalli, Prashanth, Maralekere K., Revanasiddappa, Hosakere D., Veeresh, Bantal |
| المصدر: | Archiv der Pharmazie ; volume 347, issue 5, page 370-380 ; ISSN 0365-6233 1521-4184 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2014 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | A series of novel 1′‐[2‐(difluoromethoxy)benzyl]‐2′ H ,5′ H ‐spiro[8‐azabicyclo[3.2.1]octane‐3,4′‐imidazolidine]‐2′,5′‐dione substituted hydantoins ( 5 – 32 ) were synthesized using an appropriate synthetic route and characterized by elemental analysis and spectral data. The novel molecules were screened for anticonvulsant activity in mice by maximal electroshock (MES) and subcutaneous pentylenetetrazol (ScPTZ)‐induced seizure tests. The neurotoxicity was assessed using the rotarod method. Compounds 9 , 10 , 18 , 30 , and 31 exhibited anticonvulsant potency against MES seizure and in the ScPTZ model, with lesser neurotoxicity. Some title compounds showed lesser central nervous system depression compared to phenytoin. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/ardp.201300289 |
| الاتاحة: | http://dx.doi.org/10.1002/ardp.201300289 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fardp.201300289 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ardp.201300289 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.43371E97 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ardp.201300289 |
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