Academic Journal
Inhibition of influenza virus infection in mice by pulmonary administration of a spray dried antiviral
| العنوان: | Inhibition of influenza virus infection in mice by pulmonary administration of a spray dried antiviral |
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| المؤلفون: | Heida, Rick, Jacob Silva, Paulo H, Akkerman, Renate, Moser, Jill, de Vries-Idema, Jacqueline, Bornet, Aurélien, Pawar, Sujeet, Stellacci, Francesco, Frijlink, Henderik W, Huckriede, Anke L W, Hinrichs, Wouter L J |
| المصدر: | Heida , R , Jacob Silva , P H , Akkerman , R , Moser , J , de Vries-Idema , J , Bornet , A , Pawar , S , Stellacci , F , Frijlink , H W , Huckriede , A L W & Hinrichs , W L J 2024 , ' Inhibition of influenza virus infection in mice by pulmonary administration of a spray dried antiviral ' , European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V , vol. 204 , 114507 . https://doi.org/10.1016/j.ejpb.2024.114507 |
| سنة النشر: | 2024 |
| المجموعة: | University of Groningen research database |
| الوصف: | Increasing resistance to antiviral drugs approved for the treatment of influenza urges the development of novel compounds. Ideally, this should be complemented by a careful consideration of the administration route. 6'siallyllactosamine-functionalized β-cyclodextrin (CD-6'SLN) is a novel entry inhibitor that acts as a mimic of the primary attachment receptor of influenza, sialic acid. In this study, we aimed to develop a dry powder formulation of CD-6'SLN to assess its in vivo antiviral activity after administration via the pulmonary route. By means of spray drying the compound together with trileucine, a dispersion enhancer, we created a powder that retained the antiviral effect of the drug, remained stable under elevated temperature conditions and performed well in a dry powder inhaler. To test the efficacy of the dry powder drug against influenza infection in vivo, infected mice were treated with CD-6'SLN using an aerosol generator that allowed for the controlled administration of powder formulations to the lungs of mice. CD-6'SLN was effective in mitigating the course of the disease compared to the control groups, reflected by lower disease activity scores and by the prevention of virus-induced IL-6 production. Our data show that CD-6'SLN can be formulated as a stable dry powder that is suitable for use in a dry powder inhaler and is effective when administered via the pulmonary route to influenza-infected mice. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1016/j.ejpb.2024.114507 |
| الاتاحة: | https://hdl.handle.net/11370/4f318835-f565-49d2-b453-5bff13ea9364 https://research.rug.nl/en/publications/4f318835-f565-49d2-b453-5bff13ea9364 https://doi.org/10.1016/j.ejpb.2024.114507 https://pure.rug.nl/ws/files/1106819568/1-s2.0-S0939641124003333-main.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.432FABCF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ejpb.2024.114507 |
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