Academic Journal
Using a polygenic score in a family design to understand genetic influences on musicality
| العنوان: | Using a polygenic score in a family design to understand genetic influences on musicality |
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| المؤلفون: | Wesseldijk, Laura W., Abdellaoui, Abdel, Gordon, Reyna L., Aslibekyan, Stella, Auton, Adam, Babalola, Elizabeth, Bell, Robert K., Bielenberg, Jessica, Bryc, Katarzyna, Bullis, Emily, Coker, Daniella, Partida, Gabriel Cuellar, Dhamija, Devika, Das, Sayantan, Elson, Sarah L., Filshtein, Teresa, Fletez-Brant, Kipper, Fontanillas, Pierre, Freyman, Will, Faaborg, Anna, Fuller, Shirin T., Gandhi, Pooja M., Heilbron, Karl, Hicks, Barry, Jewett, Ethan M., Kukar, Katelyn, Lin, Keng-Han, Lowe, Maya, McCreight, Jey C., McIntyre, Matthew H., Micheletti, Steven J., Moreno, Meghan E., Mountain, Joanna L., Nandakumar, Priyanka, Noblin, Elizabeth S., O’Connell, Jared, Huang, Yunru, Petrakovitz, Aaron A., Lane, Vanessa, Petrakovitz, Aaron, Kim, Joanne S., Poznik, G. David, Schumacher, Morgan, Shastri, Anjali J., Shelton, Janie F., Shi, Jingchunzi, Shringarpure, Suyash, Tran, Vinh, Tung, Joyce Y., Wang, Xin |
| المساهمون: | The National Institute on Deafness and Other Communication Disorders and the Office of the Director of the National Institutes of Health, The Bank of Sweden Tercentenary Foundation, The Sven and Dagmar Salén Foundation and the Marcus and Amalia Wallenberg Foundation, Karolinska Institute |
| المصدر: | Scientific Reports ; volume 12, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| الوصف: | To further our understanding of the genetics of musicality, we explored associations between a polygenic score for self-reported beat synchronization ability (PGS rhythm ) and objectively measured rhythm discrimination, as well as other validated music skills and music-related traits. Using family data, we were able to further explore potential pathways of direct genetic, indirect genetic (through passive gene–environment correlation) and confounding effects (such as population structure and assortative mating). In 5648 Swedish twins, we found PGS rhythm to predict not only rhythm discrimination, but also melody and pitch discrimination (betas between 0.11 and 0.16, p < 0.001), as well as other music-related outcomes ( p < 0.05). In contrast, PGS rhythm was not associated with control phenotypes not directly related to music. Associations did not deteriorate within families (N = 243), implying that indirect genetic or confounding effects did not inflate PGS rhythm effects. A correlation ( r = 0.05, p < 0.001) between musical enrichment of the family childhood environment and individuals' PGS rhythm , suggests gene–environment correlation. We conclude that the PGS rhythm captures individuals' general genetic musical propensity, affecting musical behavior more likely direct than through indirect or confounding effects. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-022-18703-w |
| الاتاحة: | http://dx.doi.org/10.1038/s41598-022-18703-w https://www.nature.com/articles/s41598-022-18703-w.pdf https://www.nature.com/articles/s41598-022-18703-w |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.4312F31A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-022-18703-w |
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