التفاصيل البيبلوغرافية
| العنوان: |
The Genetic and Immunologic Landscape Underlying the Risk of Malignant Progression in Laryngeal Dysplasia |
| المؤلفون: |
Francesco Chu, Fausto Maffini, Daniela Lepanto, Davide Vacirca, Sergio Vincenzo Taormina, Rita De Berardinis, Sara Gandini, Silvano Vignati, Alberto Ranghiero, Alessandra Rappa, Susanna Chiocca, Massimo Barberis, Marta Tagliabue, Mohssen Ansarin |
| المصدر: |
Cancers; Volume 15; Issue 4; Pages: 1117 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
laryngeal dysplasia, tumor microenvironment, immunity system, laryngeal cancer, tumor-infiltrating lymphocytes, TILs, immune system |
| الوصف: |
(1) Background: The development of laryngeal cancer is a multistep process involving structural alterations of the epithelial mucosa, from dysplasia (LDy) to invasive carcinoma. In this study, we define new biomarkers, prognostic for malignant transformation, in patients affected by LDy. (2) Methods: We used targeted next-generation sequencing and immunohistochemical analysis to define the mutational and immunological landscape of 15 laryngeal dysplasia progressing to invasive cancer (progressing dysplasia), as well as 31 cases of laryngeal dysplasia that did not progress to carcinoma (non-progressing dysplasia). Two pathologists independently analyzed the presence of tumor-infiltrating lymphocytes in LDy pre-embedded paraffin-fixed specimens. The RNA-based next-generation sequencing panel OIRRA was used to evaluate the expression of 395 genes related to immune system activation. (3) Results: High TILs are significantly correlated with a higher risk of malignant transformation. The non-brisk pattern was significantly associated with an 86% reduced risk of malignant progression (OR = 0.16, 95% CI: 0.03–0.5, p = 0.008). TILs showed a highly positive correlation with CCR6, CD83, HLA-DPB1, MX1 and SNAI1, and they were inversely correlated with CD48, CIITA, CXCR4, FCER1G, IL1B, LST1 and TLR8. (4) Conclusions: TILs have a great potential to identify high-risk progression dysplasia and thus to define surveillance protocols and prevention programs. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Cancer Epidemiology and Prevention; https://dx.doi.org/10.3390/cancers15041117 |
| DOI: |
10.3390/cancers15041117 |
| الاتاحة: |
https://doi.org/10.3390/cancers15041117 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.42FBCE0E |
| قاعدة البيانات: |
BASE |