Academic Journal
Serum cholesterol levels and the risk of multiple system atrophy: a case-control study.
| العنوان: | Serum cholesterol levels and the risk of multiple system atrophy: a case-control study. |
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| المساهمون: | Phil Hyu Lee, Tae Sung Lim, Hae-Won Shin, Seok Woo Yong, Hyo Suk Nam, Young H. Sohn, Nam, Hyo Suk, Sohn, Young Ho, Lee, Phil Hyu |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Aged, Case-Control Studies, Cholesterol/blood, Cholesterol, HDL, LDL, Female, Humans, Male, Middle Aged, Multiple System Atrophy/blood, Multiple System Atrophy/etiology, Odds Ratio, Retrospective Studies, Risk Factors, Severity of Illness Index, Statistics as Topic, multiple system atrophy, total cholesterol, HDL�릀holesterol |
| الوصف: | Cholesterol in brain membranes may modulate the conformational state and accumulation of alpha-synuclein in alpha-synucleinopathies.We examined the association between serum cholesterol and the risk of multiple system atrophy (MSA), one of the alpha-synucleinopathies. We enrolled 142 patients with probable MSA from two tertiary referral hospitals and 155 age- and gender-matched healthy people with no neurological disease. The levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were significantly lower in MSA patients than in controls (total cholesterol: 172.7 vs. 196.3 mg/dL, P < 0.001; LDL-C: 104.0 vs. 115.3 mg/dL, P = 0.001; HDL-C: 47.3 vs. 54.2 mg/dL, P < 0.001). After adjusting for age, gender, use of cholesterol-lowering drugs, and histories of hypertension, diabetes mellitus, and smoking, the odds ratios was 5.9 (95% CI = 2.3-11.5, P < 0.001) for MSA patients in the lowest quartile of total cholesterol and 2.6 (95% CI = 1.2-5.5, P = 0.016) for those in the lowest quartile of HDL-C, compared with the highest quartiles. Levels of serum cholesterol did not significantly correlate with disease duration or severity. Our data suggest that lower levels of total cholesterol and HDL may be associated with an increased risk of MSA ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 752~758 |
| اللغة: | unknown |
| تدمد: | 0885-3185 1531-8257 |
| Relation: | MOVEMENT DISORDERS; J02275; OAK-2009-00551; https://ir.ymlib.yonsei.ac.kr/handle/22282913/103891; T200901299; MOVEMENT DISORDERS, Vol.24(5) : 752-758, 2009 |
| DOI: | 10.1002/mds.22459 |
| DOI: | 10.1002/mds.22459/abstract |
| الاتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103891 https://doi.org/10.1002/mds.22459 http://onlinelibrary.wiley.com/doi/10.1002/mds.22459/abstract |
| Rights: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ |
| رقم الانضمام: | edsbas.42F658A1 |
| قاعدة البيانات: | BASE |
| تدمد: | 08853185 15318257 |
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| DOI: | 10.1002/mds.22459 |