Academic Journal
Electrospray fabrication of pH‐responsive microspheres for the delivery of Ozoile
| العنوان: | Electrospray fabrication of pH‐responsive microspheres for the delivery of Ozoile |
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| المؤلفون: | Ciarleglio, Gianluca, Russo, Tiziana, Vella, Serena, Toto, Elisa, Santonicola, Maria Gabriella |
| المساهمون: | Ciarleglio, Gianluca, Russo, Tiziana, Vella, Serena, Toto, Elisa, Santonicola, Maria Gabriella |
| بيانات النشر: | WILEY-V C H VERLAG GMBH POSTFACH 101161, 69451 WEINHEIM, GERMANY |
| سنة النشر: | 2024 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | drug delivery system, electrospray, hydrogel, microsphere, stimuli-sensitive polymers |
| الوصف: | Microspheres (MSs) made from biocompatible natural polymers with pH-responsive properties, such as alginate and chitosan, are widely exploited as drug delivery systems. In this work, pH-responsive MS based on alginate/chitosan hydrogels is developed and applied as carriers of Ozoile, a stable ozonide. Ozoile is a bioactive formulation obtained by ozonation of biological olive oil, which is capable of inducing the expression of different genes that are involved in the process of tissue regeneration. The MS containing Ozoile is prepared using an electrospray (ES) technique from alginate/Ozoile emulsions. The MSs are optimized with a chitosan coating to improve their stability and degradation behavior, and so to control the release of Ozoile in time. Fourier transform infrared (FTIR) spectroscopy, swelling, and degradation analyses are conducted and results use to assess the potential use of the alginate-based MS for the therapeutic release of Ozoile at specific inflammatory sites. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:001293226800052; volume:413; issue:4; firstpage:1; lastpage:3; numberofpages:3; journal:MACROMOLECULAR SYMPOSIA; https://hdl.handle.net/11573/1717796; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85201430183 |
| DOI: | 10.1002/masy.202400031 |
| الاتاحة: | https://hdl.handle.net/11573/1717796 https://doi.org/10.1002/masy.202400031 |
| رقم الانضمام: | edsbas.42D0EA68 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/masy.202400031 |
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