Academic Journal
Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain.
| العنوان: | Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain. |
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| المؤلفون: | Lepko, Tjasa, Pusch, Melanie, Modic, Miha, Martin-Villalba, Ana, Zhao, Sheng, LLorens-Bobadilla, Enric, Schneider, Anja, Fischer, Andre, Breunig, Christopher T, Stricker, Stefan H, Götz, Magdalena, Ninkovic, Jovica, Müller, Tamara, Schulte, Dorothea, Ehses, Janina, Kiebler, Michael, Hasler, Julia, Huttner, Hagen B, Vandenbroucke, Roosmarijn E, Vandendriessche, Charysse |
| المصدر: | The EMBO journal 38(17), e100481 (2019). doi:10.15252/embj.2018100481 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/570, Adult, Animals, Cell Cycle, Cell Differentiation, Cell Movement, Choroid Plexus: chemistry, Female, Gene Expression Regulation, Humans, Male, Mice, MicroRNAs: cerebrospinal fluid, MicroRNAs: genetics, Middle Aged, Neural Stem Cells: chemistry, Neural Stem Cells: cytology, Stem Cell Niche, MIRN204 microRNA, human, mouse, MicroRNAs |
| جغرافية الموضوع: | DE |
| الوصف: | Regulation of adult neural stem cell (NSC) number is critical for lifelong neurogenesis. Here, we identified a post-transcriptional control mechanism, centered around the microRNA 204 (miR-204), to control the maintenance of quiescent (q)NSCs. miR-204 regulates a spectrum of transcripts involved in cell cycle regulation, neuronal migration, and differentiation in qNSCs. Importantly, inhibition of miR-204 function reduced the number of qNSCs in the subependymal zone (SEZ) by inducing pre-mature activation and differentiation of NSCs without changing their neurogenic potential. Strikingly, we identified the choroid plexus of the mouse lateral ventricle as the major source of miR-204 that is released into the cerebrospinal fluid to control number of NSCs within the SEZ. Taken together, our results describe a novel mechanism to maintain adult somatic stem cells by a niche-specific miRNA repressing activation and differentiation of stem cells. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/pmid:31304985; info:eu-repo/semantics/altIdentifier/issn/1460-2075; info:eu-repo/semantics/altIdentifier/issn/0261-4189; https://pub.dzne.de/record/140933; https://pub.dzne.de/search?p=id:%22DZNE-2020-07255%22 |
| الاتاحة: | https://pub.dzne.de/record/140933 https://pub.dzne.de/search?p=id:%22DZNE-2020-07255%22 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.42B59644 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |