Academic Journal
DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE)
| العنوان: | DITERPENOS ENT-ABIETANOS DE Euphorbia phosphorea (EUPHORBIACEAE) |
|---|---|
| المؤلفون: | Roseana A. R. Meireles, Lucas S. Abreu, Joanda Paolla R. e Silva, Andreza B. S. Cavalcanti, Renata Priscila B. de Menezes, Gabriela Cristina S. Rodrigues, Valnês S. Rodrigues Junior, José Iranildo M. de Melo, Massuo Jorge Kato, Vicente Carlos de O. Costa, Marcus Tullius Scotti, Josean F. Tavares |
| المصدر: | Química Nova, Vol 45, Iss 9, Pp 1092-1097 (2022) |
| بيانات النشر: | Sociedade Brasileira de Química |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Chemistry, QD1-999 |
| الوصف: | Phytochemical study of the roots of Euphorbia phosphorea Mart. (Euphorbiaceae) was carried out through chromatographic techniques, resulting in the isolation of a new ent-abietane diterpene named 11β,12β-dihydroxy-ent-abieta-8(14),13(15)-dien-16,12α-olide (1), and of nine known ent-abietane diterpenes jolkinolide A (2), jolkinolide E (3), euphorin H (4), euphopilolide (5) jolkinolide F (6), ent-12-hydroxy-12[R]-abieta-8(14),13(15)-dien-16,12-olide (7), ent-11α-hydroxyabieta-8(14),13(15)-dien-16,12α-olide (8), 17-hydroxyjolkinolide B (9) and caudicifolin (10). The structures of all compounds were established using spectroscopic techniques such as 1D and 2D NMR, and the structure of the compound 1 was established also with MS, IR and ECD. All compounds were submitted to an in silico study through of a predictive model and then submitted to in vitro tests against Mycobacterium tuberculosis and M. smegmatis for evaluation of their antimycobacterial activity. Compounds 5 and 9 showed mycobacterial growth inhibition with MIC values of 62.5 μM against M. tuberculosis and M. smegmatis, respectively. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English Spanish; Castilian Portuguese |
| تدمد: | 1678-7064 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422022000901092&tlng=pt; https://doaj.org/toc/1678-7064; https://doaj.org/article/070f5ccd2c1a436ba6baf3b633ae21b9 |
| DOI: | 10.21577/0100-4042.20170932 |
| الاتاحة: | https://doi.org/10.21577/0100-4042.20170932 https://doaj.org/article/070f5ccd2c1a436ba6baf3b633ae21b9 |
| رقم الانضمام: | edsbas.42AB5E99 |
| قاعدة البيانات: | BASE |
| تدمد: | 16787064 |
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| DOI: | 10.21577/0100-4042.20170932 |