Academic Journal
Improvement of Urolithin A Yield by In Vitro Cofermentation of Streptococcus thermophilus FUA329 with Human Gut Microbiota from Different Urolithin Metabotypes
| العنوان: | Improvement of Urolithin A Yield by In Vitro Cofermentation of Streptococcus thermophilus FUA329 with Human Gut Microbiota from Different Urolithin Metabotypes |
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| المؤلفون: | Mengjie Xia, Ziyan Hua, Yaling Zhao, Gewen Zhang, Xiaoyue Hou, Guang Yang, Shu Liu, Yaowei Fang |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biochemistry, Microbiology, Ecology, Developmental Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, thereby significantly increasing, produce highly bioavailable, determined using high, streptococcus thermophilus <, human gut microbiota, streptococcus thermophilus fua329, strain fua329 modulated, strain fua329 increased, multibiologically active uro, different urolithin metabotypes, urolithin metabotype 0, 0 gut microbiota, gut microbiota, thermophilus fua329, strain fua329, different ums, harmful microbiota, beneficial microbiota, throughput sequencing, significant increase, results revealed, greatest interest, experimental group |
| الوصف: | Streptococcus thermophilus FUA329 converts ellagic acid (EA) to urolithin A (Uro-A), which is not autonomously converted by the gut microbiota to produce highly bioavailable and multibiologically active Uro-A in urolithin metabotype 0 (UM-0) populations. We consider that Streptococcus thermophilus FUA329 has the potential to be developed as a probiotic. Therefore, we utilized S. thermophilus FUA329 for in vitro cofermentation with gut microbiota. The results revealed that strain FUA329 increased the production of EA-converted Uro-A during in vitro cofermentation with the human gut microbiota of different urolithin metabotypes (UMs), with a significant increase in the production of Uro-A in the experimental group of UM-0. In addition, changes in the in vitro cofermentation microbial community were determined using high-throughput sequencing. Strain FUA329 modulated the structure and composition of the gut microbiota in different UMs, thereby significantly increasing the abundance of beneficial microbiota in the gut microbiota while decreasing the abundance of harmful microbiota. Of greatest interest was the significant increase in the abundance of Actinobacteria phylum after the cofermentation of strain FUA329 with UM-0 gut microbiota, which might be related to the significant increase in the production of Uro-A. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Improvement_of_Urolithin_A_Yield_by_In_Vitro_Cofermentation_of_i_Streptococcus_thermophilus_i_FUA329_with_Human_Gut_Microbiota_from_Different_Urolithin_Metabotypes/25130218 |
| DOI: | 10.1021/acs.jafc.3c09734.s001 |
| الاتاحة: | https://doi.org/10.1021/acs.jafc.3c09734.s001 https://figshare.com/articles/journal_contribution/Improvement_of_Urolithin_A_Yield_by_In_Vitro_Cofermentation_of_i_Streptococcus_thermophilus_i_FUA329_with_Human_Gut_Microbiota_from_Different_Urolithin_Metabotypes/25130218 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.42454A28 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.jafc.3c09734.s001 |
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