Academic Journal
Insight into m 6 A methylation from occurrence to functions
| العنوان: | Insight into m 6 A methylation from occurrence to functions |
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| المؤلفون: | Ru, Wenxiu, Zhang, Xiaoyan, Yue, Binglin, Qi, Ao, Shen, Xuemei, Huang, Yongzhen, Lan, Xianyong, Lei, Chuzhao, Chen, Hong |
| المساهمون: | the National Natural Science Foundation of China |
| المصدر: | Open Biology ; volume 10, issue 9 ; ISSN 2046-2441 |
| بيانات النشر: | The Royal Society |
| سنة النشر: | 2020 |
| الوصف: | RNA m 6 A methylation is a post-transcriptional modification that occurs at the nitrogen-6 position of adenine. This dynamically reversible modification is installed, removed and recognized by methyltransferases, demethylases and readers, respectively. This modification has been found in most eukaryotic mRNA, tRNA, rRNA and other non-coding RNA. Recent studies have revealed important regulatory functions of the m 6 A including effects on gene expression regulation, organism development and cancer development. In this review, we summarize the discovery and features of m 6 A, and briefly introduce the mammalian m 6 A writers, erasers and readers. Finally, we discuss progress in identifying additional functions of m 6 A and the outstanding questions about the regulatory effect of this widespread modification. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1098/rsob.200091 |
| الاتاحة: | http://dx.doi.org/10.1098/rsob.200091 https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200091 https://royalsocietypublishing.org/doi/full-xml/10.1098/rsob.200091 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.4231A4D7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1098/rsob.200091 |
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