Academic Journal
MYO10-filopodia support basement membranes at pre-invasive tumor boundaries
| العنوان: | MYO10-filopodia support basement membranes at pre-invasive tumor boundaries |
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| المؤلفون: | Peuhu, Emilia, Jacquemet, Guillaume, Scheele, Colinda L G J, Isomursu, Aleksi, Laisne, Marie-Catherine, Koskinen, Leena M, Paatero, Ilkka, Thol, Kerstin, Georgiadou, Maria, Guzmán, Camilo, Koskinen, Satu, Laiho, Asta, Elo, Laura L, Boström, Pia, Hartiala, Pauliina, van Rheenen, Jacco, Ivaska, Johanna |
| المصدر: | Peuhu , E , Jacquemet , G , Scheele , C L G J , Isomursu , A , Laisne , M-C , Koskinen , L M , Paatero , I , Thol , K , Georgiadou , M , Guzmán , C , Koskinen , S , Laiho , A , Elo , L L , Boström , P , Hartiala , P , van Rheenen , J & Ivaska , J 2022 , ' MYO10-filopodia support basement membranes at pre-invasive tumor boundaries ' , Developmental Cell , vol. 57 , no. 20 , pp. 2350-2364.e7 . https://doi.org/10.1016/j.devcel.2022.09.016 |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Humans, Female, Carcinoma, Intraductal, Noninfiltrating/metabolism, Pseudopodia/metabolism, Breast Neoplasms/pathology, Myosins/metabolism, Basement Membrane/metabolism, Ductal, Breast/metabolism |
| الوصف: | Ductal carcinoma in situ (DCIS) is a pre-invasive stage of breast cancer. During invasion, the encapsulating DCIS basement membrane (BM) is compromised, and tumor cells invade the surrounding stroma. The mechanisms that regulate functional epithelial BMs in vivo are poorly understood. Myosin-X (MYO10) is a filopodia-inducing protein associated with metastasis and poor clinical outcome in invasive breast cancer (IBC). We identify elevated MYO10 expression in human DCIS and IBC, and this suggests links with disease progression. MYO10 promotes filopodia formation and cell invasion in vitro and cancer-cell dissemination from progressively invasive human DCIS xenografts. However, MYO10-depleted xenografts are more invasive. These lesions exhibit compromised BMs, poorly defined borders, and increased cancer-cell dispersal and EMT-marker-positive cells. In addition, cancer spheroids are dependent on MYO10-filopodia to generate a near-continuous extracellular matrix boundary. Thus, MYO10 is protective in early-stage breast cancer, correlating with tumor-limiting BMs, and pro-invasive at later stages, facilitating cancer-cell dissemination. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1016/j.devcel.2022.09.016 |
| الاتاحة: | https://research.abo.fi/en/publications/f46b5619-aef3-4273-a5c6-a58bdb507f8f https://doi.org/10.1016/j.devcel.2022.09.016 https://research.abo.fi/ws/files/47247658/1_s2.0_S1534580722007134_main.pdf https://urn.fi/URN:NBN:fi-fe202301162874 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.42319F23 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.devcel.2022.09.016 |
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