Academic Journal
Impact of dietary and obesity genetic risk scores on weight gain.
| العنوان: | Impact of dietary and obesity genetic risk scores on weight gain. |
|---|---|
| المؤلفون: | Baratali, L., Mean, M., Marques-Vidal, P. |
| المصدر: | The American journal of clinical nutrition, vol. 114, no. 2, pp. 741-751 |
| سنة النشر: | 2021 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Aged, Cross-Sectional Studies, Diet/adverse effects, Diet/standards, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Obesity/genetics, Weight Gain/genetics, dietary intake, gene-diet interactions, obesity, prospective study, weight gain |
| الوصف: | Whether genetic background and/or dietary behaviors influence weight gain in middle-aged subjects is debated. To assess whether genetic background and/or dietary behaviors are associated with changes in obesity markers (BMI, weight, and waist and hip circumferences) in a Swiss population-based cohort. Cross-sectional and prospective (follow-up of 5.3 y) study. Two obesity genetic risk scores (GRS) based on 31 or 68 single nucleotide polymorphisms were used. Dietary intake was assessed using a semiquantitative FFQ. Three dietary patterns "Meat & fries" (unhealthy), "Fruits & vegetables" (healthy), and "Fatty & sugary" (unhealthy), and 3 dietary scores (2 Mediterranean and the Alternative Healthy Eating Index [AHEI]) were computed. On cross-sectional analysis (N = 3033, 53.2% females, 58.4 ± 10.6 y), obesity markers were positively associated with unhealthy dietary patterns and GRS, and negatively associated with healthy dietary scores and patterns. On prospective analysis (N = 2542, 54.7% females, age at baseline 58.0 ± 10.4 y), the AHEI and the "Fruits & vegetables" pattern were negatively associated with waist circumference gain: multivariate-adjusted average ± SE 0.96 ± 0.25 compared with 0.11 ± 0.26 cm (P for trend 0.044), and 1.14 ± 0.26 compared with -0.05 ± 0.26 cm (P for trend 0.042) for the first and fourth quartiles of the AHEI and the "Fruits & vegetables" pattern, respectively. Similar inverse associations were obtained for changes in waist >5 cm: multivariate-adjusted OR (95% CI): 0.65 (0.50, 0.85) and 0.67 (0.51, 0.89) for the fourth versus the first quartile of the AHEI and the "Fruits & vegetables" dietary pattern, respectively. No associations were found between GRS and changes in obesity markers, and no significant gene-diet interactions were found. Dietary intake, not GRS, are associated with waist circumference in middle-aged subjects living in Lausanne, Switzerland. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33831948; info:eu-repo/semantics/altIdentifier/eissn/1938-3207; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_3D45D9B2B0E13; https://serval.unil.ch/notice/serval:BIB_3D45D9B2B0E1; https://serval.unil.ch/resource/serval:BIB_3D45D9B2B0E1.P001/REF.pdf |
| DOI: | 10.1093/ajcn/nqab069 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_3D45D9B2B0E1 https://doi.org/10.1093/ajcn/nqab069 https://serval.unil.ch/resource/serval:BIB_3D45D9B2B0E1.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_3D45D9B2B0E13 |
| Rights: | info:eu-repo/semantics/openAccess ; Copying allowed only for non-profit organizations ; https://serval.unil.ch/disclaimer |
| رقم الانضمام: | edsbas.41E25B3F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ajcn/nqab069 |
|---|