Academic Journal
Preliminary experience with a transcranial magnetic resonance-guided focused ultrasound surgery system integrated with a 1.5-T MRI unit in a series of patients with essential tremor and Parkinson's disease
| العنوان: | Preliminary experience with a transcranial magnetic resonance-guided focused ultrasound surgery system integrated with a 1.5-T MRI unit in a series of patients with essential tremor and Parkinson's disease |
|---|---|
| المؤلفون: | Iacopino, Domenico Gerardo, Gagliardo, Cesare, Giugno, Antonella, Giammalva, Giuseppe Roberto, Napoli, Alessandro, Maugeri, Rosario, Graziano, Francesca, Valentino, Francesca, Cosentino, Giuseppe, D'Amelio, Marco, Bartolotta, Tommaso Vincenzo, Catalano, Carlo, Fierro, Brigida, Midiri, Massimo, Lagalla, Roberto |
| المساهمون: | Iacopino, D., Gagliardo, C., Giugno, A., Giammalva, G., Napoli, A., Maugeri, R., Graziano, F., Valentino, F., Cosentino, G., D'Amelio, M., Bartolotta, T., Catalano, C., Fierro, B., Midiri, M., Lagalla, R. |
| بيانات النشر: | American Association of Neurological Surgeons |
| سنة النشر: | 2018 |
| المجموعة: | IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: | magnetic resonance–guided focused ultrasound surgery, MRgFUS, high-intensity focused ultrasound ablation, brain, stereotactic technique, Parkinson’s disease, essential tremor, MRI, interventional, Settore MED/26 - Neurologia, Settore MED/27 - Neurochirurgia, Settore MED/36 - Diagnostica Per Immagini E Radioterapia, Settore MED/37 - Neuroradiologia |
| الوصف: | OBJECTIVE Transcranial magnetic resonance-guided focused ultrasound surgery (tcMRgFUS) is one of the emerging noninvasive technologies for the treatment of neurological disorders such as essential tremor (ET), idiopathic asymmetrical tremor-dominant Parkinson's disease (PD), and neuropathic pain. In this clinical series the authors present the preliminary results achieved with the world's first tcMRgFUS system integrated with a 1.5-T MRI unit. METHODS The authors describe the results of tcMRgFUS in a sample of patients with ET and with PD who underwent the procedure during the period from January 2015 to September 2017. A monolateral ventralis intermedius nucleus (VIM) thalamic ablation was performed in both ET and PD patients. In all the tcMRgFUS treatments, a 1.5-T MRI scanner was used for both planning and monitoring the procedure. RESULTS During the study period, a total of 26 patients underwent tcMRgFUS thalamic ablation for different movement disorders. Among these patients, 18 were diagnosed with ET and 4 were affected by PD. All patients with PD were treated using tcMRgFUS thalamic ablation and all completed the procedure. Among the 18 patients with ET, 13 successfully underwent tcMRgFUS, 4 aborted the procedure during ultrasound delivery, and 1 did not undergo the tcMRgFUS procedure after stereotactic frame placement. Two patients with ET were not included in the results because of the short follow-up duration at the time of this study. A monolateral VIM thalamic ablation in both ET and PD patients was performed. All the enrolled patients were evaluated before the treatment and 2 days after, with a clinical control of the treatment effectiveness using the graphic items of the Fahn-Tolosa-Marin tremor rating scale. A global reevaluation was performed 3 months (17/22 patients) and 6 months (11/22 patients) after the treatment; the reevaluation consisted of clinical questionnaires, neurological tests, and video recordings of the tests. All the ET and PD treated patients who completed the procedure showed ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/29385927; info:eu-repo/semantics/altIdentifier/wos/WOS:000423808800007; volume:44; issue:2; firstpage:1; lastpage:10; numberofpages:10; journal:NEUROSURGICAL FOCUS; http://hdl.handle.net/10447/264594 |
| DOI: | 10.3171/2017.11.FOCUS17614 |
| الاتاحة: | http://hdl.handle.net/10447/264594 https://doi.org/10.3171/2017.11.FOCUS17614 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.41D6B48D |
| قاعدة البيانات: | BASE |
| DOI: | 10.3171/2017.11.FOCUS17614 |
|---|