التفاصيل البيبلوغرافية
| العنوان: |
The mycobacterial guaB1 gene encodes a guanosine 5 monophosphate reductase with a cystathionine beta synthase domain |
| المؤلفون: |
Knejzlik, Z., Dolezal, M., Herkommerova, K., Clarova, K., Klima, M., Dedola, M., Zbornikova, E., Rejman, D., Pichova, I. |
| سنة النشر: |
2022 |
| المجموعة: |
Helmholtz Zentrum Berlin (HZB): Publications |
| مصطلحات موضوعية: |
Mycobacterium, CBS domain, GMPR |
| الوصف: |
Mycobacteria express enzymes from both the de novo and purine salvage pathways. However, the regulation of these processes and the roles of individual metabolic enzymes have not been sufficiently detailed. Both Mycobacterium amp; 8201;tuberculosis Mtb and Mycobacterium amp; 8201;smegmatis Msm possess three guaB genes, but information is only available on guaB2, which encodes an essential inosine 5 amp; 8242; monophosphate dehydrogenase IMPDH involved in de novo purine biosynthesis. This study shows that guaB1, annotated in databases as a putative IMPDH, encodes a guanosine 5 amp; 8242; monophosphate reductase GMPR , which recycles guanosine monophosphate to inosine monophosphate within the purine salvage pathway and contains a cystathionine amp; 946; synthase domain CBS , which is essential for enzyme activity. GMPR activity is allosterically regulated by the ATP GTP ratio in a pH dependent manner. Bioinformatic analysis has indicated the presence of GMPRs containing CBS domains across the entire Actinobacteria phylum |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
http://www.helmholtz-berlin.de/pubbin/oai_publication?VT=1&ID=107400 |
| الاتاحة: |
http://www.helmholtz-berlin.de/pubbin/oai_publication?VT=1&ID=107400 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.41CA21CF |
| قاعدة البيانات: |
BASE |