Academic Journal
Drug dosage individualization based on a random-effects linear lodel
| العنوان: | Drug dosage individualization based on a random-effects linear lodel |
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| المؤلفون: | Diaz, Francisco J., Cogollo, Myladis R., Spina, Edoardo, Santoro, Vincenza, Rendon, Diego M., de Leon, Jose |
| المساهمون: | Universidad EAFIT. Escuela de Ciencias, Modelado Matemático |
| المصدر: | Journal Of Biopharmaceutical Statistics |
| بيانات النشر: | TAYLOR & FRANCIS INC |
| سنة النشر: | 2012 |
| المجموعة: | Universidad EAFIT, Medellin: Repositorio Institucional |
| مصطلحات موضوعية: | clozapine, fluoxetine, fluvoxamine, paroxetine, phenobarbital, valproic acid, algorithm, article, clinical practice, comparative study, computer simulation, dose calculation, dose response, drug blood level, drug dose sequence, drug monitoring, human, individualization, optimal drug dose, personalized medicine, priority journal, schizophrenia, smoking, statistical model, steady state, Dose-Response Relationship, Drug, Humans, Individualized Medicine, Linear Models |
| الوصف: | This article investigates drug dosage individualization when the patient population can be described with a random-effects linear model of a continuous pharmacokinetic or pharmacodynamic response. Specifically, we show through both decision-theoretic arguments and simulations that a published clinical algorithm may produce better individualized dosages than some traditional methods of therapeutic drug monitoring. Since empirical evidence suggests that the linear model may adequately describe drugs and patient populations, and linear models are easier to handle than the nonlinear models traditionally used in population pharmacokinetics, our results highlight the potential applicability of linear mixed models to dosage computations and personalized medicine. Copyright © Taylor & Francis Group, LLC. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 10543406 15205711 |
| Relation: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859191400&doi=10.1080%2f10543406.2010.547264&partnerID=40&md5=5233b238e63b9e257ccb59f654518199; https://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1369; WOS;000304678600003; PUBMED;22416835; SCOPUS;2-s2.0-84859191400; http://hdl.handle.net/10784/27756 |
| DOI: | 10.1080/10543406.2010.547264 |
| الاتاحة: | http://hdl.handle.net/10784/27756 https://eafit.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1369 https://doi.org/10.1080/10543406.2010.547264 |
| Rights: | https://v2.sherpa.ac.uk/id/publication/issn/1054-3406 |
| رقم الانضمام: | edsbas.41967A1B |
| قاعدة البيانات: | BASE |
| تدمد: | 10543406 15205711 |
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| DOI: | 10.1080/10543406.2010.547264 |