Academic Journal
Modulation of neural response to happy and sad faces by acute tryptophan depletion
| العنوان: | Modulation of neural response to happy and sad faces by acute tryptophan depletion |
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| المؤلفون: | FUSAR POLI, PAOLO, Allen P, Lee F, Surguladze S, Tunstall N, Fu CH, Brammer MJ, Cleare AJ, Mcguire P.K. |
| المساهمون: | FUSAR POLI, Paolo, Allen, P, Lee, F, Surguladze, S, Tunstall, N, Fu, Ch, Brammer, Mj, Cleare, Aj, Mcguire, P. K. |
| سنة النشر: | 2007 |
| المجموعة: | IRIS UNIPV (Università degli studi di Pavia) |
| مصطلحات موضوعية: | Acute tryptophan depletion, Serotonin, fMRI Emotional processing, Ekman face, Depression |
| الوصف: | BACKGROUND: Central serotonin (5HT) plays a major role in emotional processing. We used functional neuroimaging (fMRI) to investigate the effects of experimental manipulation of central 5HT levels on the regional neural response to happy and sad facial expressions. METHODS: Ten healthy participants (eight men and two women) were scanned during an implicit emotional processing task after receiving a tryptophan-free (acute tryptophan depletion, ATD) or a balanced amino acid drink in a double-blind design. RESULTS: ATD lowered total plasma tryptophan concentration by 80%. There was no significant effect on subjective mood ratings, on response accuracy and on reaction times. Compared to sham depletion, ATD attenuated activation in the right medial/inferior frontal gyrus, the posterior cingulate cortex, the occipital and parietal cortex bilaterally, the right hippocampus, claustrum and insula. Conversely, ATD was associated with relatively increased activation in the left inferior frontal gyrus. ATD had differential effects on activation during the processing of happy and sad faces in the right putamen and in the left superior temporal gyrus. CONCLUSIONS: In both cortical and sub-cortical regions, the neural response associated with processing emotional faces is significantly modulated by 5HT manipulation resulting from ATD. Moreover, in certain areas, this effect of 5HT depends on the emotional valence of the stimulus. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/17375288; info:eu-repo/semantics/altIdentifier/wos/WOS:000247244100003; volume:193; issue:1; firstpage:31; lastpage:44; journal:PSYCHOPHARMACOLOGY; http://hdl.handle.net/11571/35561; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-34250182798 |
| DOI: | 10.1007/s00213-007-0757-4 |
| الاتاحة: | http://hdl.handle.net/11571/35561 https://doi.org/10.1007/s00213-007-0757-4 |
| رقم الانضمام: | edsbas.4184E34B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00213-007-0757-4 |
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