Academic Journal
Implementation of population screening for colorectal cancer by repeated Fecal Immunochemical Test (FIT): third round
| العنوان: | Implementation of population screening for colorectal cancer by repeated Fecal Immunochemical Test (FIT): third round |
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| المؤلفون: | Stegeman Inge, de Wijkerslooth Thomas R, Mallant-Hent Rosalie C, de Groot Karin, Stroobants An K, Fockens Paul, Mundt Marco, Bossuyt Patrick MM, Dekker Evelien |
| المصدر: | BMC Gastroenterology, Vol 12, Iss 1, p 73 (2012) |
| بيانات النشر: | BMC |
| سنة النشر: | 2012 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Background Colorectal cancer (CRC) is the most common cancer in Europe with a mortality rate of almost 50%. The prognosis of patients is largely determined by the clinical and pathological stage at the time of diagnosis. Population screening has been shown to reduce CRC-related mortality rate. Most screening programs worldwide rely on fecal immunochemical testing (FIT). The effectiveness of a FIT screening program is not only influenced by initial participation rate, but also by program adherence during consecutive screening rounds. We aim to evaluate the participation rate in and yield of a third CRC screening round using FIT. Methods and design Four years after the first screening round and two years after the second round, a total number of approximately 11,000 average risk individuals (50 to 75 years of age) will be invited to participate in a third round of FIT-based CRC screening. We will select individuals in the same target area as in the previous screening rounds, using the electronic database of the regional municipal administration registrations. We will invite all FIT-negatives and all non-participants in previous screening rounds, as well as eligible first time invitees who have moved into the area or have become 50 years of age. FITs will be analyzed in the special technique laboratory of the Academic Medical Center of the University of Amsterdam. All FIT-positives will be invited for a consultation at the outpatient clinic. In the absence of contra-indications, a colonoscopy will follow at the Academic Medical Center or at the Flevohospital. The primary outcome measures are the participation rate, defined as the proportion of invitees that return a FIT in this third round of FIT-screening, and the diagnostic yield of the program. Implications This study will provide precise data on the participation in later FIT screening rounds. This enables to estimate the effectiveness of CRC screening programs that rely on repeated FIT- screening, such as the one that will be implemented in the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1471-230X |
| Relation: | http://www.biomedcentral.com/1471-230X/12/73; https://doaj.org/toc/1471-230X; https://doaj.org/article/22ec312ca063470d9928dca7ac531deb |
| DOI: | 10.1186/1471-230X-12-73 |
| الاتاحة: | https://doi.org/10.1186/1471-230X-12-73 https://doaj.org/article/22ec312ca063470d9928dca7ac531deb |
| رقم الانضمام: | edsbas.41740A08 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1471230X |
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| DOI: | 10.1186/1471-230X-12-73 |