Academic Journal
Loss of BRM expression is a frequently observed event in poorly differentiated clear cell renal cell carcinoma
| العنوان: | Loss of BRM expression is a frequently observed event in poorly differentiated clear cell renal cell carcinoma |
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| المؤلفون: | Xia, Qiu‐yuan, Rao, Qiu, Cheng, Liang, Shen, Qin, Shi, Shan‐shan, Li, Li, Liu, Biao, Zhang, Jin, Wang, Yan‐fen, Shi, Qun‐li, Wang, Jian‐dong, Ma, Heng‐hui, Lu, Zhen‐feng, Yu, Bo, Zhang, Ru‐song, Zhou, Xiao‐jun |
| المصدر: | Histopathology ; volume 64, issue 6, page 847-862 ; ISSN 0309-0167 1365-2559 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2014 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Aims The aim of this study was to examine the status of Brahma (BRM), a key SWI / SNF complex subunit, in clear cell renal cell carcinomas ( RCC s), and to analyse the histopathology, immunophenotype, molecular features and prognosis of the BRM ‐negative cases. Methods and results We identified 19 cases of grade 4 tumours lacking BRM expression among 625 clear cell RCC s. All 19 cases exhibited features of poor differentiation: 13 showed pure poorly differentiated morphology, while six were composite tumours with an admixed typical low‐grade component. Besides negative BRM expression, the immunophenotype of these cases was similar to clear cell RCC . VHL gene mutations were identified in nine of the 19 patients (47%). Chromosome 3p deletion was detected in 11 of 13 poorly differentiated RCC s and both areas of five of five composite tumours. All poorly differentiated tumour areas showed polysomy of chromosome 3. No losses or gains of chromosome 3 were observed in low‐grade tumour areas of five of five composite RCC s. Conclusions We have shown that loss of BRM expression is a common feature among poorly differentiated tumours in clear cell RCC s. We hypothesize that loss of BRM expression is involved in tumor de‐differentiation in clear cell RCC s and may play an important role during tumour progression. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/his.12334 |
| الاتاحة: | http://dx.doi.org/10.1111/his.12334 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fhis.12334 https://onlinelibrary.wiley.com/doi/pdf/10.1111/his.12334 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.413E03E2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/his.12334 |
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