Academic Journal
Diastereoselective and Enantioselective Synthesis of Unsymmetric beta,beta-Diaryl-alpha-Amino Acid Esters via Organocatalytic 1,6-Conjugate Addition of para-Quinone Methides
| العنوان: | Diastereoselective and Enantioselective Synthesis of Unsymmetric beta,beta-Diaryl-alpha-Amino Acid Esters via Organocatalytic 1,6-Conjugate Addition of para-Quinone Methides |
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| المؤلفون: | Zhang, Xiang-Zhi, Deng, Yu-Hua, Yan, Xu, Yu, Ke-Yin, Wang, Fang-Xin, Ma, Xiao-Yan, Fan, Chun-An |
| المساهمون: | Fan, CA (reprint author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, 222 Tianshui Nanlu, Lanzhou 730000, Peoples R China., Fan, CA (reprint author), Peking Univ, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Lu, Beijing 100191, Peoples R China., Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, 222 Tianshui Nanlu, Lanzhou 730000, Peoples R China., Peking Univ, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Lu, Beijing 100191, Peoples R China., Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China. |
| المصدر: | EI ; SCI |
| بيانات النشر: | JOURNAL OF ORGANIC CHEMISTRY |
| سنة النشر: | 2016 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | ALPHA-AMINO-ACIDS, PHASE-TRANSFER CATALYSIS, BETA-SUBSTITUTED TRYPTOPHANS, RING-OPENING REACTIONS, ASYMMETRIC-SYNTHESIS, INHIBITORY-ACTIVITY, EXPEDIENT ACCESS, DERIVATIVES, ALKYLATION, GLYCINE |
| الوصف: | A novel strategy based on phase transfer catalysis for the diastereoselective and enantioselective direct assembly of unsymmetric beta,beta-diaryl-alpha-amino acid esters via 1,6-conjugate addition of para-quinone methides and glycine derivatives is described. This protocol also provides an alternative route to the synthetically interesting functionalized chiral tetrahydroisoquinoline and its analogues. ; National Natural Science Foundation of China [21572083, 21322201, 21290180]; Fundamental Research Funds for the Central Universities [lzujbky-2015-48]; State Key Laboratory of Natural and Biomimetic Drugs [K20150213]; PCSIRT [IRT_15R28]; 111 Project of Ministry of Education of China [111-2-17]; Chang Jiang Scholars Program ; SCI(E) ; EI ; ARTICLE ; fanchunan@lzu.edu.cn ; 13 ; 5655-5662 ; 81 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0022-3263 |
| Relation: | JOURNAL OF ORGANIC CHEMISTRY.2016,81(13),5655-5662.; 1432862; http://hdl.handle.net/20.500.11897/492051; WOS:000379456500041 |
| DOI: | 10.1021/acs.joc.6b00390 |
| الاتاحة: | https://hdl.handle.net/20.500.11897/492051 https://doi.org/10.1021/acs.joc.6b00390 |
| رقم الانضمام: | edsbas.41182EC2 |
| قاعدة البيانات: | BASE |
| تدمد: | 00223263 |
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| DOI: | 10.1021/acs.joc.6b00390 |