Academic Journal
Assessing cytokine status of patients with chronic endometritis combined with endometrial hyperplastic processes in reproductive period ; Оценка цитокинового статуса у пациенток с хроническим эндометритом в сочетании с гиперпластическими процессами эндометрия в репродуктивном периоде
| العنوان: | Assessing cytokine status of patients with chronic endometritis combined with endometrial hyperplastic processes in reproductive period ; Оценка цитокинового статуса у пациенток с хроническим эндометритом в сочетании с гиперпластическими процессами эндометрия в репродуктивном периоде |
|---|---|
| المؤلفون: | Tkachenko L.V., Sviridova N.I., Zharkin N.A., Burova N.A., Belan E.B. |
| المصدر: | Russian Journal of Infection and Immunity; Vol 10, No 4 (2020); 762-768 ; Инфекция и иммунитет; Vol 10, No 4 (2020); 762-768 ; 2313-7398 ; 2220-7619 |
| بيانات النشر: | SPb RAACI |
| سنة النشر: | 2020 |
| المجموعة: | Russian Journal of Infection and Immunity (Infektsiya i immunitet) / Инфекция и иммунитет |
| مصطلحات موضوعية: | cytokine status, chronic endometritis, endometrial hyperplastic processes, reproductive period, цитокиновый статус, хронический эндометрит, гиперпластические процессы эндометрия, репродуктивный период |
| الوصف: | The goal of our study was to examine local and serum cytokine level involved in regulating inflammation in patients with chronic endometritis combined with endometrial hyperplastic processes. On admission, all patients underwent hysteroscopy with separate diagnostic curettage followed by histological examination of samples isolated from the uterine and cervical canal mucosa. Such manipulations were indicated due to abnormal uterine bleeding as well as suspected endometrial pathology based on ultrasound examination. According to the histological examination data of the endometrial samples, all patients were divided into two groups: group I contained 45 women with CE combined with PEG without atypia; group II — 38 patients with morphologically verified CEE combined with AEG without atypia. Level of IL-1P, IL-2, IL-6, IFNy, TNFa in biological fluids (aspirate from the uterus; serum) was measured by using enzyme-linked immunosorbent assay. We found that in both groups (91.1% and 89.6%, respectively) the vast majority of patients was hospitalized due to abnormal uterine bleeding. Oligomenorrhea alternated with intermenstrual bleeding (66.7% and 71.2%, respectively) and dominated in pattern of menstrual cycle disorders in the examined patients, whereas 11 (24.4%) and 7 (18.4%) patients from group I and II, respectively, were noted to suffer from severe menstrual bleeding. Overall, analyzing the data on cytokine level both in the uterine aspirate and serum evidences about ongoing inflammatory process found at examination time point. Upon that, such process was not only local, but also exhibited signs of a systemic inflammatory response. The data on cytokine level in the uterine aspirate from patients with CE coupled to PGE or CGE without atypia point at local inflammatory process characterized by significantly increased concentration of IL-ф, IL-2, IL-6, TNFa and IFNy. At the same time, higher level of IL-ф and IFNy in patients from group II might indicates that degree of morphological changes in the endometrium could ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Russian |
| Relation: | https://iimmun.ru/iimm/article/view/1357/1145; https://iimmun.ru/iimm/article/view/1357 |
| DOI: | 10.15789/2220-7619-AOC-1357 |
| الاتاحة: | https://iimmun.ru/iimm/article/view/1357 https://doi.org/10.15789/2220-7619-AOC-1357 |
| Rights: | Copyright (c) 2020 Tkachenko L.V., Sviridova N.I., Zharkin N.A., Burova N.A., Belan E.B. ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.41150264 |
| قاعدة البيانات: | BASE |
| DOI: | 10.15789/2220-7619-AOC-1357 |
|---|