Academic Journal
Investigation of gene-environment interactions in relation to tic severity
| العنوان: | Investigation of gene-environment interactions in relation to tic severity |
|---|---|
| المؤلفون: | Abdulkadir, M, Yu, D, Osiecki, L, King, RA, Fernandez, TV, Brown, LW, Cheon, K-A, Coffey, BJ, Garcia-Delgar, B, Gilbert, DL, Grice, DE, Hagstrøm, J, Hedderly, T, Heyman, I, Hong, HJ, Huyser, C, Ibanez-Gomez, L, Kim, YK, Kim, Y-S, Koh, Y-J, Kook, S, Kuperman, S, Leventhal, B, Madruga-Garrido, M, Maras, A, Mir, P, Morer, A, Münchau, A, Plessen, KJ, Roessner, V, Shin, E-J, Song, D-H, Song, J, Visscher, F, Zinner, SH, Mathews, CA, Scharf, JM, Tischfield, JA, Heiman, GA, Dietrich, A, Hoekstra, PJ |
| المصدر: | Journal of Neural Transmission , 128 pp. 1757-1765. (2021) |
| بيانات النشر: | Springer Verlag |
| سنة النشر: | 2021 |
| المجموعة: | University College London: UCL Discovery |
| الوصف: | Tourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investigated genetic loci previously implicated in Tourette syndrome and associated disorders in interaction with pre- and perinatal adversity in relation to tic severity using a case-only (N = 518) design. We assessed 98 single-nucleotide polymorphisms (SNPs) selected from (I) top SNPs from genome-wide association studies (GWASs) of TS; (II) top SNPs from GWASs of obsessive–compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD); (III) SNPs previously implicated in candidate-gene studies of TS; (IV) SNPs previously implicated in OCD or ASD; and (V) tagging SNPs in neurotransmitter-related candidate genes. Linear regression models were used to examine the main effects of the SNPs on tic severity, and the interaction effect of these SNPs with a cumulative pre- and perinatal adversity score. Replication was sought for SNPs that met the threshold of significance (after correcting for multiple testing) in a replication sample (N = 678). One SNP (rs7123010), previously implicated in a TS meta-analysis, was significantly related to higher tic severity. We found a gene–environment interaction for rs6539267, another top TS GWAS SNP. These findings were not independently replicated. Our study highlights the future potential of TS GWAS top hits in gene–environment studies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/10132096/9/Heyman_Abdulkadir2021_Article_InvestigationOfGeneEnvironment.pdf; https://discovery.ucl.ac.uk/id/eprint/10132096/ |
| الاتاحة: | https://discovery.ucl.ac.uk/id/eprint/10132096/9/Heyman_Abdulkadir2021_Article_InvestigationOfGeneEnvironment.pdf https://discovery.ucl.ac.uk/id/eprint/10132096/ |
| Rights: | open |
| رقم الانضمام: | edsbas.4089C829 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |