Academic Journal
A Quantitative Trait Locus on chr.4 Regulates Thymic Involution
| العنوان: | A Quantitative Trait Locus on chr.4 Regulates Thymic Involution |
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| المؤلفون: | Kumar, Ritu, Avagyan, Serine, Snoeck, Hans-Willem |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2010 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Article |
| الوصف: | The mechanisms underlying age-associated thymic involution are unknown. In mice, thymic involution shows mouse strain–dependent genetic variation. Identification of the underlying genes would provide mechanistic insight into this elusive process. We previously showed that responsiveness of hematopoietic stem and progenitor cells (HSPCs) to transforming growth factor-beta 2, a positive regulator of HSPC proliferation, is regulated by a quantitative trait locus (QTL) on chr. 4, Tb2r1 . Interestingly, Tgfb2+/− mice have delayed thymic involution. Therefore, we tested the hypothesis that a QTL on chr. 4 might regulate thymic involution. Aged, but not young, B6.D2-chr.4 congenic mice, where the telomeric region of chr. 4 was introgressed from DBA/2 to C57BL/6 mice, had larger thymi, and better maintenance of early thymic precursors than C57BL/6 control mice. These observations unequivocally demonstrate that the telomeric region of chr. 4 contains a QTL, Ti1 (thymic involution 1) that regulates thymic involution, and suggest the possibility that Ti1 may be identical to Tb2r1 . |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://biomedgerontology.oxfordjournals.org/cgi/content/short/glq041v1; http://dx.doi.org/10.1093/gerona/glq041 |
| DOI: | 10.1093/gerona/glq041 |
| الاتاحة: | http://biomedgerontology.oxfordjournals.org/cgi/content/short/glq041v1 https://doi.org/10.1093/gerona/glq041 |
| Rights: | Copyright (C) 2010, The Gerontological Society of America |
| رقم الانضمام: | edsbas.402278C7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/gerona/glq041 |
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