التفاصيل البيبلوغرافية
| العنوان: |
Assessing and Modulating Kynurenine Pathway Dynamics in Huntington's Disease: Focus on Kynurenine 3-Monooxygenase. |
| المؤلفون: |
Korrapati V. Sathyasaikumar, Carlo Breda, Robert Schwarcz, Flaviano Giorgini |
| سنة النشر: |
2018 |
| المجموعة: |
University of Leicester: Figshare |
| مصطلحات موضوعية: |
Uncategorized, Huntington’s disease, Kynurenine 3-monooxygenase (KMO), Kynurenine pathway, huntingtin, KMO |
| الوصف: |
The link between disturbances in kynurenine pathway (KP) metabolism and Huntington's disease (HD) pathogenesis has been explored for a number of years. Several novel genetic and pharmacological tools have recently been developed to modulate key regulatory steps in the KP such as the reaction catalyzed by the enzyme kynurenine 3-monooxygenase (KMO). This insight has offered new options for exploring the mechanistic link between this metabolic pathway and HD, and provided novel opportunities for the development of candidate drug-like compounds. Here, we present an overview of the field, focusing on some novel approaches for interrogating the pathway experimentally. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
2381/10208546.v1; https://figshare.com/articles/journal_contribution/Assessing_and_Modulating_Kynurenine_Pathway_Dynamics_in_Huntington_s_Disease_Focus_on_Kynurenine_3-Monooxygenase_/10208546 |
| الاتاحة: |
https://figshare.com/articles/journal_contribution/Assessing_and_Modulating_Kynurenine_Pathway_Dynamics_in_Huntington_s_Disease_Focus_on_Kynurenine_3-Monooxygenase_/10208546 |
| Rights: |
All Rights Reserved |
| رقم الانضمام: |
edsbas.3FDA6FAE |
| قاعدة البيانات: |
BASE |