Academic Journal
Enhanced antimicrobial activity of biocompatible bacterial cellulose films via dual synergistic action of curcumin and triangular silver nanoplates
| العنوان: | Enhanced antimicrobial activity of biocompatible bacterial cellulose films via dual synergistic action of curcumin and triangular silver nanoplates |
|---|---|
| المؤلفون: | Lanzagorta Garcia, Eduardo, Mojicevic, Marija, Milivojevic, Dusan, Aleksic, Ivana, Vojnovic, Sandra, Stevanovic, Milena, Murray, James, Attallah, Olivia Adly, Devine, Declan M., Brennan Fournet, Margaret |
| المساهمون: | Technological University of the Shannon Midlands Midwest, This project received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 870292 (BioICEP) and was supported by the National Natural Science Foundation of China (grant numbers: Institute of Microbiology, Chinese Academy of Sciences: 31961133016, Beijing Institute of Technology: 31961133015, Shandong Univer sity: 31961133014). This project also received funding from a part of the Interreg VB NWE Programme, project number NWE1058 (CURCOL). |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Bacterial cellulose, Silver nanoparticles, Curcumin, Antimicrobial properties, Biopolymers, Zebrafish, PRISM: Polymer, Recycling, Industrial, Sustainability and Manufacturing Institute |
| الوصف: | Curcumin and triangular silver nanoplates (TSNP)-incorporated bacterial cellulose (BC) films present an ideal antimicrobial material for biomedical applications as they afford a complete set of requirements, including a broad range of long-lasting potency and superior efficacy antimicrobial activity, combined with low toxicity. Here, BC was produced by Komagataeibacter medellinensis ID13488 strain in the presence of curcumin in the production medium (2 and 10%). TSNP were incorporated in the produced BC/curcumin films using ex situ method (21.34 ppm) and the antimicrobial activity was evaluated against Escherichia coli ATCC95922 and Staphylococcus aureus ATCC25923 bacterial strains. Biological activity of these natural products was assessed in cytotoxicity assay against lung fibroblasts and in vivo using Caenorhabditis elegans and Danio rerio as model organisms. Derived films have shown excellent antimicrobial performance with growth inhibition up to 67% for E. coli and 95% for S. aureus. In a highly positive synergistic interaction, BC films with 10% curcumin and incorporated TSNP have shown reduced toxicity with 80% MRC5 cells survival rate. It was shown that only 100% concentrations of film extracts induce low toxicity effect on model organisms’ development. The combined and synergistic advanced anti-infective functionalities of the curcumin and TSNP incorporated in BC have a high potential for development for application within the clinical setting. ; yes |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | PDF; application/pdf |
| اللغة: | English |
| Relation: | International Journal of Molecular Sciences; Garcia, E.L.; Mojicevic, M.; Milivojevic, D.; Aleksic, I.; Vojnovic, S.; Stevanovic, M.; Murray, J.; Attallah, O.A.; Devine, D.; Fournet, M.B. (2022). Enhanced Antimicrobial Activity of Biocompatible Bacterial Cellulose Films via Dual Synergistic Action of Curcumin and Triangular Silver Nanoplates. International Journal of Molecular Sciences. 23, 12198. https://doi.org/10.3390/ ijms232012198; https://research.thea.ie/handle/20.500.12065/4317 |
| الاتاحة: | https://research.thea.ie/handle/20.500.12065/4317 https://hdl.handle.net/20.500.12065/4317 |
| Rights: | Attribution-NonCommercial-NoDerivs 3.0 United States ; http://creativecommons.org/licenses/by-nc-nd/3.0/us/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3F7A3847 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |