Academic Journal
Parvovirus B19 activates in vitro normal human dermal fibroblasts: a possible implication in skin fibrosis and systemic sclerosis
| العنوان: | Parvovirus B19 activates in vitro normal human dermal fibroblasts: a possible implication in skin fibrosis and systemic sclerosis |
|---|---|
| المؤلفون: | Arvia, Rosaria, Margheri, Francesca, Stincarelli, Maria A, Laurenzana, Anna, Fibbi, Gabriella, Gallinella, Giorgio, Ferri, Clodoveo, Del Rosso, Mario, Zakrzewska, Krystyna |
| المساهمون: | Arvia, Rosaria, Margheri, Francesca, Stincarelli, Maria A, Laurenzana, Anna, Fibbi, Gabriella, Gallinella, Giorgio, Ferri, Clodoveo, Del Rosso, Mario, Zakrzewska, Krystyna |
| سنة النشر: | 2020 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | fibrosi, normal human dermal fibroblast, parvovirus B19 infection, systemic sclerosis |
| الوصف: | Fibrosis is the most characteristic pathological hallmark of SSc, a connective tissue disease characterized by vascular and immunological abnormalities, inflammation and enhanced extracellular matrix production, leading to progressive fibrosis of skin and internal organs. We previously demonstrated that parvovirus B19 (B19V) can infect normal human dermal fibroblasts (NHDFs) and that B19V persists in SSc fibroblasts. In this study, we investigated whether parvovirus B19V is able to activate in vitro NHDFs and to induce in these cells some phenotypic features similar to that observed in the SSc fibroblasts. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/32556240; info:eu-repo/semantics/altIdentifier/wos/WOS:000593174200065; volume:59; issue:11; firstpage:3526; lastpage:3532; numberofpages:7; journal:RHEUMATOLOGY; https://hdl.handle.net/11585/766024; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85090824472; https://academic.oup.com/rheumatology/article/59/11/3526/5859205 |
| DOI: | 10.1093/rheumatology/keaa230 |
| الاتاحة: | https://hdl.handle.net/11585/766024 https://doi.org/10.1093/rheumatology/keaa230 https://academic.oup.com/rheumatology/article/59/11/3526/5859205 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3F7290F3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/rheumatology/keaa230 |
|---|