Academic Journal
Upregulation of the enzyme chain hydrolyzing extracellular ATP after transient forebrain ischemia in the rat
| العنوان: | Upregulation of the enzyme chain hydrolyzing extracellular ATP after transient forebrain ischemia in the rat |
|---|---|
| المؤلفون: | Norbert Braun, Yuan Zhu, Josef Krieglstein, Carsten Culmsee, Herbert Zimmermann |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.jneurosci.org/content/18/13/4891.full.pdf. |
| سنة النشر: | 1998 |
| المجموعة: | CiteSeerX |
| الوصف: | A short ischemic period induced by the transient occlusion of major brain arteries induces neuronal damage in selectively vulnerable regions of the hippocampus. Adenosine is considered to be one of the major neuroprotective substances produced in the ischemic brain. It can be released from damaged cells, but it also could be generated extracellularly from released ATP via a surface-located enzyme chain. Using the rat model of global forebrain ischemia, we applied a short (10 min) transient interruption of blood flow and studied the distribution of ectonucleotidase activities in the hippocampus. Northern hybridization of mRNA isolated from hippocampi of shamoperated and ischemic animals revealed an upregulation of ectoapyrase (capable of hydrolyzing nucleoside 5�-tri- and diphosphates) and ecto-5�-nucleotidase (capable of hydrolyzing nucleoside 5�-monophosphates). A histochemical analysis |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.7967; http://www.jneurosci.org/content/18/13/4891.full.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.7967 http://www.jneurosci.org/content/18/13/4891.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.3F4D52 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |