Academic Journal
Factors associated with shunt dynamic in patients with cryptogenic stroke and patent foramen ovale: an observational cohort study
| العنوان: | Factors associated with shunt dynamic in patients with cryptogenic stroke and patent foramen ovale: an observational cohort study |
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| المؤلفون: | Allendörfer Jens, Sieweke Nicole, Grebe Mathias, Puille Maximilian, Tanislav Christian, Pabst Wolfgang, Kaps Manfred, Reichenberger Frank |
| المصدر: | BMC Cardiovascular Disorders, Vol 11, Iss 1, p 54 (2011) |
| بيانات النشر: | BMC |
| سنة النشر: | 2011 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Background As previously reported there is evidence for a reduction in right to left shunt (RLS) in stroke patients with patent foramen ovale (PFO). This occurs predominantly in patients with cryptogenic stroke (CS). We therefore analysed factors associated with a shunt reduction on follow-up in stroke patients suffering of CS. Methods On index event PFO and RLS were proven by transesophageal echocardiography and contrast-enhanced transcranial Doppler-sonography (ce-TCD). Silent PE was proved by ventilation perfusion scintigraphy (V/Q) within the stroke work-up on index event; all scans were re-evaluated in a blinded manner by two experts. The RLS was re-assessed on follow-up by ce-TCD. A reduction in shunt volume was defined as a difference of ≥20 microembolic signals (MES) or the lack of evidence of RLS on follow-up. For subsequent analyses patients with CS were considered; parameters such as deep vein thrombosis (DVT) and silent pulmonary embolism (PE) were analysed. Results In 39 PFO patients suffering of a CS the RLS was re-assessed on follow-up. In all patients (n = 39) with CS a V/Q was performed; the median age was 40 years, 24 (61.5%) patients were female. In 27 patients a reduction in RLS was evident. Silent PE was evident in 18/39 patients (46.2%). Factors such as atrial septum aneurysm, DVT or even silent PE were not associated with RLS dynamics. A greater time delay from index event to follow-up assessment was associated with a decrease in shunt volume (median 12 vs. 6 months, p = 0.013). Conclusions In patients with CS a reduction in RLS is not associated with the presence of a venous embolic event such as DVT or silent PE. A greater time delay between the initial and the follow-up investigation increases the likelihood for the detection of a reduction in RLS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1471-2261 |
| Relation: | http://www.biomedcentral.com/1471-2261/11/54; https://doaj.org/toc/1471-2261; https://doaj.org/article/732d77abd7f742cd88a3213d1daa1a31 |
| DOI: | 10.1186/1471-2261-11-54 |
| الاتاحة: | https://doi.org/10.1186/1471-2261-11-54 https://doaj.org/article/732d77abd7f742cd88a3213d1daa1a31 |
| رقم الانضمام: | edsbas.3F1785E4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14712261 |
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| DOI: | 10.1186/1471-2261-11-54 |