Academic Journal
Inactivation of native K channels
| العنوان: | Inactivation of native K channels |
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| المؤلفون: | Kodirov, Sodikdjon, Brachmann, Johannes, Safonova, Tatiana A., Zhuravlev, Vladimir L. |
| بيانات النشر: | Springer Nature |
| سنة النشر: | 2021 |
| المجموعة: | Universidade de Lisboa: repositório.UL |
| مصطلحات موضوعية: | Heart, Helix, Inactivation, K+ currents, Mollusk, Tail |
| الوصف: | © 2021 The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. ; We have experimented with isolated cardiomyocytes of mollusks Helix. During the whole-cell patch-clamp recordings of K+ currents a considerable decrease in amplitude was observed upon repeated voltage steps at 0.96 Hz. For these experiments, ventricular cells were depolarized to identical + 20 mV from a holding potential of - 50 mV. The observed spontaneous inhibition of outward currents persisted in the presence of 4-aminopyridine, tetraethylammonium chloride or E-4031, the selective class III antiarrhythmic agent that blocks HERG channels. Similar tendency was retained when components of currents sensitive to either 4-AP or TEA were mathematically subtracted. Waveforms of currents sensitive to 1 and 10 micromolar concentration of E-4031 were distinct comprising prevailingly those activated during up to 200 ms pulses. The outward current activated by a voltage ramp at 60 mV x s-1 rate revealed an inward rectification around + 20 mV. This feature closely resembles those of the mammalian cardiac delayed rectifier IKr. ; info:eu-repo/semantics/publishedVersion |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0022-2631 1432-1424 |
| Relation: | https://www.springer.com/journal/232; J Membr Biol. 2021 Aug 12. doi:10.1007/s00232-021-00195-w; http://hdl.handle.net/10451/49629 |
| DOI: | 10.1007/s00232-021-00195-w |
| الاتاحة: | http://hdl.handle.net/10451/49629 https://doi.org/10.1007/s00232-021-00195-w |
| Rights: | restrictedAccess |
| رقم الانضمام: | edsbas.3ECECB3E |
| قاعدة البيانات: | BASE |
| تدمد: | 00222631 14321424 |
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| DOI: | 10.1007/s00232-021-00195-w |