Academic Journal
Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice
| العنوان: | Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice |
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| المؤلفون: | Park, Kwang-Kyun, Chun, Kyung-Soo, Lee, Jong-Min, Lee, Sang Sup, Surh, Young-Joon |
| المساهمون: | 서영준, Surh, Young-Joon |
| سنة النشر: | 1998 |
| المجموعة: | Seoul National University: S-Space |
| مصطلحات موضوعية: | [6]-gingerol, antitumor promotion, anti-inflammation, curcumin, chemoprevention, HL-60 cells |
| الوصف: | A wide array of phytochemicals have been shown to possess potential cancer chemopreventive properties. Ginger contains pungent phenolic substances with pronounced antioxidative and antiinflammatory activities. In the present study, we have determined the antitumor promotional activity of [6]-gingerol, a major pungent principle of ginger, using a two-stage mouse skin carcinogenesis model. Topical application of [6]-gingerol onto shaven backs of female ICR mice prior to each topical dose of 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited 7,12-dimethylbenz[a]anthracene-induced skin papillomagenesis. The compound also suppressed TPA-induced epidermal ornithine decarboxylase activity and inflammation. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0304-3835 |
| Relation: | Cancer Letters, Vol.129 No.2, pp.139-144; 5273; https://hdl.handle.net/10371/172919; 2-s2.0-0032547010; https://www.sciencedirect.com/science/article/pii/S0304383598000810?via%3Dihub; 000075200300003 |
| DOI: | 10.1016/S0304-3835(98)00081-0 |
| الاتاحة: | https://hdl.handle.net/10371/172919 https://doi.org/10.1016/S0304-3835(98)00081-0 https://www.sciencedirect.com/science/article/pii/S0304383598000810?via%3Dihub |
| رقم الانضمام: | edsbas.3EB62E04 |
| قاعدة البيانات: | BASE |
| تدمد: | 03043835 |
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| DOI: | 10.1016/S0304-3835(98)00081-0 |