Academic Journal
What Goes Around, Comes Around – HSV-1 Replication in Monocyte-Derived Dendritic Cells
| العنوان: | What Goes Around, Comes Around – HSV-1 Replication in Monocyte-Derived Dendritic Cells |
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| المؤلفون: | Grosche, Linda, Kummer, Mirko, Steinkasserer, Alexander |
| سنة النشر: | 2017 |
| المجموعة: | OPUS FAU - Online publication system of Friedrich-Alexander-Universität Erlangen-Nürnberg |
| مصطلحات موضوعية: | ddc:610 |
| الوصف: | HSV-1 is a very successful human pathogen, known for its high sero-prevalence and the ability to infect a wide range of different cell types, including dendritic cells (DCs). As very potent antigen-presenting cells DCs play an important role in the induction of antiviral immune responses and therefore represent a strategic target for viral-mediated immune escape mechanisms. It is known that HSV-1 completes its gene expression profile in immature as well as in mature DCs, while lytic infection is only found in immature DCs (iDCs). Notably, HSV-1 infected mature DCs (mDCs) fail to release infectious progeny virions into the supernatant. Apart from HSV-1 dissemination via extracellular routes cell-to-cell spread counteracts a yet unknown mechanism by which the virus is trapped in mDCs and not released into the supernatant. The dissemination in a cell–cell contact-dependent manner enables HSV-1 to infect bystander cells without the exposure toward the extracellular environment. This supports the virus to successfully infect the host and establish latency. In this review the mechanism of HSV-1 replication in iDCs and mDCs and its immunological as well as virological implications, will be discussed. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/10828; urn:nbn:de:bvb:29-opus4-108287; https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-108287; https://doi.org/10.3389/fmicb.2017.02149; https://opus4.kobv.de/opus4-fau/files/10828/Grosche_what.pdf |
| DOI: | 10.3389/fmicb.2017.02149 |
| الاتاحة: | https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/10828 https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-108287 https://doi.org/10.3389/fmicb.2017.02149 https://opus4.kobv.de/opus4-fau/files/10828/Grosche_what.pdf |
| Rights: | https://creativecommons.org/licenses/by/4.0/deed.de ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3E8B7B04 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fmicb.2017.02149 |
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