التفاصيل البيبلوغرافية
| العنوان: |
Tumor Stroma Ratio and Its Significance in Locally Advanced Colorectal Cancer |
| المؤلفون: |
Luz Sullivan, Richard R. Pacheco, Michel Kmeid, Anne Chen, Hwajeong Lee |
| المصدر: |
Current Oncology; Volume 29; Issue 5; Pages: 3232-3241 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
colorectal cancer, tumor stroma ratio, tumor microenvironment, tumor budding, immune cells |
| الوصف: |
Colorectal cancer is the third leading cause of cancer-related death, and its incidence is rising in the younger patient population. In the past decade, research has unveiled several processes (underlying tumorigenesis, many of which involve interactions between tumor cells and the surrounding tissue or tumor microenvironment (TME). Interactions between components of the TME are mediated at a sub-microscopic level. However, the endpoint of those interactions results in morphologic changes which can be readily assessed at microscopic examination of biopsy and resection specimens. Among these morphologic changes, alteration to the tumor stroma is a new, important determinant of colorectal cancer progression. Different methodologies to estimate the proportion of tumor stroma relative to tumor cells, or tumor stroma ratio (TSR), have been developed. Subsequent validation has supported the prognostic value, reproducibility and feasibility of TSR in various subgroups of colorectal cancer. In this manuscript, we review the literature surrounding TME in colorectal cancer, with a focus on tumor stroma ratio. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Gastrointestinal Oncology; https://dx.doi.org/10.3390/curroncol29050263 |
| DOI: |
10.3390/curroncol29050263 |
| الاتاحة: |
https://doi.org/10.3390/curroncol29050263 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.3E82FBA3 |
| قاعدة البيانات: |
BASE |