Academic Journal
www.wjgnet.com GASTRIC CANCER
| العنوان: | www.wjgnet.com GASTRIC CANCER |
|---|---|
| المؤلفون: | Tadateru Maehata, Hiroaki Taniguchi, Hiroyuki Yamamoto, Katsuhiko Nosho, Yasushi Adachi, Nobuki Miyamoto, Chie Miyamoto, Noriyuki Akutsu, Satoshi Yamaoka, Fumio Itoh, Tadateru Maehata Fumio Itoh, Contributions Maehata T, Taniguchi H, Miyamoto C Analyzed Data, Maehata T |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.wjgnet.com/1007-9327/14/2702.pdf. |
| سنة النشر: | 2008 |
| المجموعة: | CiteSeerX |
| الوصف: | AIM: To clarify alterations of Dickkopfs (Dkks) and Kremen2 (Krm2) in gastrointestinal cancer. METHODS: We investigated the expression profiles and epigenetic alterations of Dkks and Krm2 genes in gastrointestinal cancer using RT-PCR, tissue microarray analysis, and methylation specific PCR (MSP). Cancer cells were treated with the demethylating agent and/or histone deacetylase inhibitor. WST-8 assays and in vitro invasion assays after treatment with specific siRNA for those genes were performed. RESULTS: Dkks and Krm2 expression levels were reduced in a certain subset of the gastrointestinal cancer cell lines and cancer tissues. This was correlated with promoter hypermethylation. There were significant |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.626.1723; http://www.wjgnet.com/1007-9327/14/2702.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.626.1723 http://www.wjgnet.com/1007-9327/14/2702.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.3E21518D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |