Academic Journal
Circulating Polymorphonuclear Myeloid-Derived Suppressor Cells (PMN-MDSCs) Have a Biological Role in Patients with Primary Myelofibrosis
| العنوان: | Circulating Polymorphonuclear Myeloid-Derived Suppressor Cells (PMN-MDSCs) Have a Biological Role in Patients with Primary Myelofibrosis |
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| المؤلفون: | Rita Campanelli, Adriana Carolei, Paolo Catarsi, Carlotta Abbà, Emanuela Boveri, Marco Paulli, Raffaele Gentile, Monica Morosini, Riccardo Albertini, Stefania Mantovani, Margherita Massa, Giovanni Barosi, Vittorio Rosti |
| المصدر: | Cancers, Vol 16, Iss 14, p 2556 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | primary myelofibrosis, myeloid-derived suppressor cells, inflammation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by a chronic inflammatory state that plays a relevant role in the disease pathogenesis (as proven by high levels of inflammatory cytokines with prognostic significance and by a persistent oxidative stress) and by extensive neoangiogenesis in bone marrow (BM) and spleen. Myeloid-derived suppressor cells (MDSCs) are immature cells that expand in patients with cancer, sepsis or chronic inflammation, favoring tumor onset and progression mainly through the decrease in immune surveillance and the promotion of neoangiogenesis. In this paper, we evaluated the presence of circulating MDSCs in PMF patients, the plasmatic factors involved in their mobilization/expansion and the correlations with laboratory, genetic and clinical parameters. The data indicated that MDSCs could have a relevant role in PMF as a new pathogenic mechanism contributing to explaining the phenotypic diversity observed during the clinical course of the disease, or a potential new target for personalized treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2072-6694 |
| Relation: | https://www.mdpi.com/2072-6694/16/14/2556; https://doaj.org/toc/2072-6694; https://doaj.org/article/4adb09e464f2481eaecdec1860810eed |
| DOI: | 10.3390/cancers16142556 |
| الاتاحة: | https://doi.org/10.3390/cancers16142556 https://doaj.org/article/4adb09e464f2481eaecdec1860810eed |
| رقم الانضمام: | edsbas.3E13350B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726694 |
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| DOI: | 10.3390/cancers16142556 |