التفاصيل البيبلوغرافية
| العنوان: |
Genome analysis of multidrug resistant bacteria from patients with cystic fibrosis ; Analyse génomique des bactéries multi-résistantes chez des patients atteints de mucoviscidose |
| المؤلفون: |
Sharma, Poonam |
| المساهمون: |
Aix-Marseille, Rolain, Jean-Marc |
| المصدر: |
Theses.fr |
| سنة النشر: |
2013 |
| مصطلحات موضوعية: |
Mucoviscidose, génomes bactériens, espèces émergents, poumon microbiome et résistance, Cystic fibrosis, whole genome sequencing, emerging species, lung microbiome and resistome, envir, socio |
| الوصف: |
Cystic fibrosis is an autosomal genetic disorder caused by a mutation in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene. Pulmonary infection is the major problem faced by patients with cystic fibrosis. My work is divided into two main parts: first I made a review of the literature on the analysis of bacterial genomes isolated from CF patients compared to the genomes of the same species isolated in autrescontextes and other part I analyzed the genomes of three species of bacteria (Microbacterium yannicii, Chryseobacterium oranimense and Haemophilus parahaemolyticus). The comprehensive analysis of bacterial genomes from cystic fibrosis patients revealed an extraordinary evolution of these genomes with time and treatment received by these patients reflects the ability of these bacteria to adapt to their particular ecosystem the acquisition of new genes by lateral gene transfer. This work shows the extraordinary plasticity of bacterial genomes in a given environment and as the lungs of patients with cystic fibrosis represents a unique model for understanding the evolution of bacterial genomes. In addition, our work has identified their molecular mechanisms of resistance to antibiotics. Future work on the study of metagenomes sampling in these patients could help to answer these questions in the future. The discovery of new species and / or emerging will allow us to have a more complete picture of cystic fibrosis which could lead to a better understanding of the disease and thus a better therapeutic management. ; La mucoviscidose est une maladie génétique autosomique causée par une mutation dans le gène CFTR (Cystic Fibrosis Transmembrane Conductance Regulator). Mon travail s’est décomposé en deux parties principales : d’une part j’ai réalisé une revue de la littérature sur l’analyse des génomes bactériens isolés de patients mucoviscidosiques comparativement aux génomes des mêmes espèces isolées dans d’autrescontextes et d’autre part j’ai analysé les génomes de trois espèces bactériennes ... |
| نوع الوثيقة: |
thesis |
| اللغة: |
English |
| Relation: |
10670/1.5hcidz; http://www.theses.fr/2013AIXM5096 |
| الاتاحة: |
http://www.theses.fr/2013AIXM5096 |
| Rights: |
other |
| رقم الانضمام: |
edsbas.3DB8947D |
| قاعدة البيانات: |
BASE |