Academic Journal
The COVID-19 Assessment for Survival at Admission (CASA) Index: A 12 Months Observational Study
| العنوان: | The COVID-19 Assessment for Survival at Admission (CASA) Index: A 12 Months Observational Study |
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| المؤلفون: | Bagnato, Gianluca, La Rosa, Daniela, Ioppolo, Carmelo, De Gaetano, Alberta, Chiappalone, Marianna, Zirilli, Natalia, Viapiana, Valeria, Tringali, Maria Concetta, Tomeo, Simona, Aragona, Caterina Oriana, Napoli, Francesca, Lillo, Sara, Irrera, Natasha, Roberts, William Neal, Imbalzano, Egidio, Micari, Antonio, Ventura Spagnolo, Elvira, Squadrito, Giovanni, Gangemi, Sebastiano, Versace, Antonio Giovanni |
| المصدر: | Frontiers in Medicine ; volume 8 ; ISSN 2296-858X |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2021 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Objective: Coronavirus disease 2019 (COVID-19) is a disease with a high rate of progression to critical illness. However, the stratification of patients at risk of mortality is not well defined. In this study, we aimed to define a mortality risk index to allocate patients to the appropriate intensity of care. Methods: This is a 12 months observational longitudinal study designed to develop and validate a pragmatic mortality risk score to stratify COVID-19 patients aged ≥18 years and admitted to hospital between March 2020 and March 2021. Main outcome was in-hospital mortality. Results: 244 patients were included in the study (mortality rate 29.9%). The Covid-19 Assessment for Survival at Admission (CASA) index included seven variables readily available at admission: respiratory rate, troponin, albumin, CKD-EPI, white blood cell count, D-dimer, Pa02/Fi02. The CASA index showed high discrimination for mortality with an AUC of 0.91 (sensitivity 98.6%; specificity 69%) and a better performance compared to SOFA (AUC = 0.76), age (AUC = 0.76) and 4C mortality (AUC = 0.82). The cut-off identified (11.994) for CASA index showed a negative predictive value of 99.16% and a positive predictive value of 57.58%. Conclusions: A quick and readily available index has been identified to help clinicians stratify COVID-19 patients according to the appropriate intensity of care and minimize hospital admission to patients at high risk of mortality. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fmed.2021.719976 |
| DOI: | 10.3389/fmed.2021.719976/full |
| الاتاحة: | http://dx.doi.org/10.3389/fmed.2021.719976 https://www.frontiersin.org/articles/10.3389/fmed.2021.719976/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.3D9659DA |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fmed.2021.719976 |
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