التفاصيل البيبلوغرافية
| العنوان: |
Expression of HERV Genes as Possible Biomarker and Target in Neurodegenerative Diseases |
| المؤلفون: |
Antonina Dolei, Gabriele Ibba, Claudia Piu, Caterina Serra |
| المصدر: |
International Journal of Molecular Sciences; Volume 20; Issue 15; Pages: 3706 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2019 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
HERV human endogenous retroviruses, HERV-Wenv, HERV-Kenv, multiple sclerosis, amyotrophic lateral sclerosis, neuroAIDS, neurodegeneration, TDP-43 |
| جغرافية الموضوع: |
agris |
| الوصف: |
Human endogenous retroviruses (HERVs) are genetic parasites, in-between genetics and environment. Few HERVs retain some coding capability. Sometimes, the host has the advantage of some HERV genes; conversely, HERVs may contribute to pathogenesis. The expression of HERVs depends on several factors, and is regulated epigenetically by stimuli such as inflammation, viral and microbial infections, etc. Increased expression of HERVs occurs in physiological and pathological conditions, in one or more body sites. Several diseases have been attributed to one or more HERVs, particularly neurological diseases. The key problem is to differentiate the expression of a HERV as cause or effect of a disease. To be used as a biomarker, a correlation between the expression of a certain HERV and the disease onset and/or behavior must be found. The greater challenge is to establish a pathogenic role. The criteria defining causal connections between HERVs and diseases include the development of animal models, and disease modulation in humans, by anti-HERV therapeutic antibody. So far, statistically significant correlations between HERVs and diseases have been achieved for HERV-W and multiple sclerosis; disease reproduction in transgenic animals was achieved for HERV-W and multiple sclerosis, and for HERV-K and amyotrophic lateral sclerosis. Clinical trials for both diseases are in progress. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Molecular Genetics and Genomics; https://dx.doi.org/10.3390/ijms20153706 |
| DOI: |
10.3390/ijms20153706 |
| الاتاحة: |
https://doi.org/10.3390/ijms20153706 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.3D83558 |
| قاعدة البيانات: |
BASE |