Academic Journal
A chemotaxonomic study of endemic species of genus Tanacetum from the Canary Islands
| العنوان: | A chemotaxonomic study of endemic species of genus Tanacetum from the Canary Islands |
|---|---|
| المؤلفون: | Triana, Jorge, Eiroa, José Luis, Morales, Manuel, Pérez, Francisco J., Brouard, Ignacio, Marrero, María Teresa, Estévez, Sara, Quintana, Jose, Estevez, Francisco, Castillo, Quírico A., León, Francisco |
| المساهمون: | Estevez, Francisco, Brouard, Ignacio, Quintana, Jose, Leon, Francisco, 55946071500, 6507583429, 57209945419, 57198295352, 57197103237, 6603470039, 55055343200, 53867837200, 8681043500, 7003810011, 55891218100, 7005039451, 1400733, 2831014, 12043575, 659881, 34895917, 34494, 657275, 2743847, 4613160, 128315, 384944, 9976720, 136703, WOS:Triana, J, WOS:Eiroa, JL, WOS:Morales, M, WOS:Perez, FJ, WOS:Brouard, I, WOS:Marrero, MT, WOS:Estevez, S, WOS:Quintana, J, WOS:Estevez, F, WOS:Castillo, QA, WOS:Leon, F, BU-MED |
| المصدر: | Phytochemistry[ISSN 0031-9422],v. 92, p. 87-104 |
| سنة النشر: | 2013 |
| المجموعة: | Universidad de Las Palmas de Gran Canaria: Acceda |
| مصطلحات موضوعية: | 32 Ciencias médicas, 3209 Farmacología, Occurring Terpene Derivatives, Chiliophyllum Var Heimerlei, Densum Subsp Sivasicum, Human Leukemia-Cells, Cadmeum Ssp Cadmeum, Sesquiterpene Lactones, Pyrethrum-Santolinoides, Antibacterial Activity, Liriope-Muscari, Aerial Parts |
| الوصف: | Aerial parts of Tanacetum oshanahanii collected at "Jardin Canario Viera y Clavijo", Tanacetum ptarmiciflorum collected at Los Moriscos (Tejeda), and Tanacetum ferulaceum var. latipinnum collected at Anden Verde (Agaete) in Gran Canada, Canary Islands, afforded three sesquiterpenes related to nerolidol and six sesquiterpene lactones whose structures were established on the basis of their spectroscopic data and chemical transformations. In this work we show that this type of sesquiterpene lactones could be used as chemotaxonomic markers. A series of sesquiterpene lactones described in this paper were assessed for cytotoxicity against HL-60 and 13937 cancer cell lines. The derivatives 106a and 98a displayed cytotoxic properties showing IC50 values between 5 and 11 mu M. Furthermore, we demonstrated that these selected sesquiterpene lactones induce apoptotic cell death in human leukemia cells through a mechanism that involves activation of multiple caspases and moreover cell death was found to be associated with the release of cytochrome c. ; 104 ; 87 ; 18 ; 1,088 ; 3,35 ; Q1 ; Q1 ; SCIE |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0031-9422 |
| Relation: | Evaluación de Potenciales Compuestos Antileucémicos.; Aislamiento y Sistesis de Productos Naturales Con Actividad Citostitica de Plantas de la Familia Asteraceae Endemicas de Canarias.; Phytochemistry; 92; http://hdl.handle.net/10553/48429; 84884902706; 000321596000009; WOS:000321596000009; K-5125-2014; K-5175-2014; K-5709-2014; No ID; Sí |
| DOI: | 10.1016/j.phytochem.2013.04.015 |
| الاتاحة: | http://hdl.handle.net/10553/48429 https://doi.org/10.1016/j.phytochem.2013.04.015 |
| رقم الانضمام: | edsbas.3D61A582 |
| قاعدة البيانات: | BASE |
| تدمد: | 00319422 |
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| DOI: | 10.1016/j.phytochem.2013.04.015 |