Academic Journal
Multimerization of ICP0, a herpes simplex virus immediate-early protein
| العنوان: | Multimerization of ICP0, a herpes simplex virus immediate-early protein |
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| المؤلفون: | Chen, J, Panagiotidis, C, Silverstein, S |
| المصدر: | Journal of Virology ; volume 66, issue 9, page 5598-5602 ; ISSN 0022-538X 1098-5514 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 1992 |
| الوصف: | ICP0, a herpes simplex virus immediate-early gene product, is a highly phosphorylated nuclear protein that is a potent activator of virus and host genes. Using biochemical and genetic assays employing plasmids encoding mutant forms of ICP0 and a recombinant adenovirus that expresses ICP0, we mutant forms of ICP0 and a recombinant adenovirus that expresses ICP0, we provide evidence that the protein multimerizes. Some mutant forms of ICP0 were transdominant and interfered with activation of a target reporter gene or with complementation of an ICP0-minus virus. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/jvi.66.9.5598-5602.1992 |
| الاتاحة: | http://dx.doi.org/10.1128/jvi.66.9.5598-5602.1992 https://journals.asm.org/doi/pdf/10.1128/jvi.66.9.5598-5602.1992 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.3D3A15D9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/jvi.66.9.5598-5602.1992 |
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