Academic Journal
Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder
| العنوان: | Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder |
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| المؤلفون: | Brevik, Erlend J, van Donkelaar, Marjolein M J, Weber, Heike, Sánchez-Mora, Cristina, Jacob, Christian, Rivero, Olga, Kittel-Schneider, Sarah, Garcia-Martínez, Iris, Aebi, Marcel, van Hulzen, Kimm, Cormand, Bru, Ramos-Quiroga, Josep A, IMAGE Consortium, Lesch, Klaus-Peter, Reif, Andreas, Ribasés, Marta, Franke, Barbara, Posserud, Maj-Britt, Johansson, Stefan, Lundervold, Astri J, Haavik, Jan, Zayats, Tetyana |
| المصدر: | Brevik, Erlend J; van Donkelaar, Marjolein M J; Weber, Heike; Sánchez-Mora, Cristina; Jacob, Christian; Rivero, Olga; Kittel-Schneider, Sarah; Garcia-Martínez, Iris; Aebi, Marcel; van Hulzen, Kimm; Cormand, Bru; Ramos-Quiroga, Josep A; IMAGE Consortium; Lesch, Klaus-Peter; Reif, Andreas; Ribasés, Marta; Franke, Barbara; Posserud, Maj-Britt; Johansson, Stefan; Lundervold, Astri J; Haavik, Jan; Zayats, Tetyana (2016). Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 171(5):733-747. |
| بيانات النشر: | Wiley-Blackwell Publishing, Inc. |
| سنة النشر: | 2016 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Department of Child and Adolescent Psychiatry, 610 Medicine & health, Genetics(clinical), Cellular and Molecular Neuroscience, Psychiatry and Mental health |
| الوصف: | Aggressiveness is a behavioral trait that has the potential to be harmful to individuals and society. With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome-wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. Our primary sample consisted of 1,060 adult ADHD patients (aADHD). To further explore the genetic architecture of childhood aggressiveness, we performed enrichment analyses of suggestive genome-wide associations observed in aADHD among GWA signals of dimensions of oppositionality (defiant/vindictive and irritable dimensions) in childhood ADHD (cADHD). No single polymorphism reached genome-wide significance (P < 5.00E-08). The strongest signal in aADHD was observed at rs10826548, within a long noncoding RNA gene (beta = -1.66, standard error (SE) = 0.34, P = 1.07E-06), closely followed by rs35974940 in the neurotrimin gene (beta = 3.23, SE = 0.67, P = 1.26E-06). The top GWA SNPs observed in aADHD showed significant enrichment of signals from both the defiant/vindictive dimension (Fisher's P-value = 2.28E-06) and the irritable dimension in cADHD (Fisher's P-value = 0.0061). In sum, our results identify a number of biologically interesting markers possibly underlying childhood aggressiveness and provide targets for further genetic exploration of aggressiveness across psychiatric disorders. © 2016 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1552-4841 |
| Relation: | https://www.zora.uzh.ch/id/eprint/134751/1/e89.pdf; info:pmid/27021288; urn:issn:1552-4841 |
| DOI: | 10.1002/ajmg.b.32434 |
| الاتاحة: | https://www.zora.uzh.ch/id/eprint/134751/ https://www.zora.uzh.ch/id/eprint/134751/1/e89.pdf https://doi.org/10.1002/ajmg.b.32434 |
| Rights: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) ; http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.3D248BC5 |
| قاعدة البيانات: | BASE |
| تدمد: | 15524841 |
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| DOI: | 10.1002/ajmg.b.32434 |