Academic Journal
Prognostic factors and clinical outcomes of high-dose chemotherapy followed by autologous stem cell transplantation in patients with peripheral T cell lymphoma, unspecified: complete remission at transplantation and the prognostic index of peripheral T cell lymphoma are the major factors predictive of outcome
| العنوان: | Prognostic factors and clinical outcomes of high-dose chemotherapy followed by autologous stem cell transplantation in patients with peripheral T cell lymphoma, unspecified: complete remission at transplantation and the prognostic index of peripheral T cell lymphoma are the major factors predictive of outcome |
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| المساهمون: | Deok-Hwan Yang, Won Seog Kim, Seok Jin Kim, Sung Hwa Bae, Sung Hyun Kim, In Ho Kim, Sung Soo Yoon, Yeung-Chul Mun, Ho-Jin Shin, Yee Soo Chae, Jae-Yong Kwak, Hawk Kim, Min Kyoung Kim, Jin Seok Kim, Jong Ho Won, Je-Jung Lee, Cheol Won Suh, Kim, Jin Seok |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Asian Continental Ancestry Group, Hematopoietic Stem Cell Transplantation/methods, Hematopoietic Stem Cell Transplantation/mortality, Humans, Lymphoma, T-Cell, Peripheral/mortality, Peripheral/therapy, Middle Aged, Prognosis, Retrospective Studies, Survival Analysis, Transplantation, Autologous, Treatment Outcome, Peripheral T cell lymphoma, Unspecified, Clinical outcomes, Prognostic factors |
| الوصف: | High-dose chemotherapy followed by autologous stem cell transplantation (HDT/ASCT) offers a rescue option for T cell lymphoma patients with poor prognosis. However, the effectiveness of HDT/ASCT in patients with various peripheral T cell subtypes, optimal transplant timing, and the prognostic factors that predict better outcomes, have not been identified. We retrospectively investigated the clinical outcomes and prognostic factors for HDT/ASCT in 64 Korean patients with peripheral T cell lymphoma, unspecified (PTCL-U) between March 1995 and February 2007. The median age at transplantation was 44 years (range: 15-63 years). According to the age-adjusted International Prognostic Index (a-IPI) and the prognostic index of PTCL (PIT), 8 patients (12.5%) were in the high-risk group and 16 (26.6%) had the 2-3 PIT factors, respectively. After a median follow-up of 29.7 months, the 3-year overall survival (OS) and progression-free survival (PFS) rates were 53.0% +/- 7.5% and 44.3% +/- 7.0%, respectively. Univariate analysis showed that poor performance status, high lactate dehydrogenase (LDH) levels, high a-IPI score, high PIT classes, failure to achieve complete response (CR) at transplantation, and nonfrontline transplantation were associated with poor OS. Multivariate analysis showed that failure to achieve CR at transplantation (hazard ratio [HR] 2.23; 95% confidence interval [CI] 1.78-7.93) and 2-3 PIT factors (HR 3.76; 95% CI 1.02-5.42) were independent prognostic factors for OS. Failure to achieve CR at transplantation and high PIT are negative predictable factors for survival following HDT/ASCT in patients with PTCL-U. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 118~125 |
| اللغة: | unknown |
| تدمد: | 1083-8791 1523-6536 |
| Relation: | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION; J00308; OAK-2009-01457; https://ir.ymlib.yonsei.ac.kr/handle/22282913/104797; http://www.sciencedirect.com/science/article/pii/S1083879108005089; T200903229; BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, Vol.15(1) : 118-125, 2009 |
| DOI: | 10.1016/j.bbmt.2008.11.010 |
| الاتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104797 https://doi.org/10.1016/j.bbmt.2008.11.010 http://www.sciencedirect.com/science/article/pii/S1083879108005089 |
| Rights: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ |
| رقم الانضمام: | edsbas.3D1E8210 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10838791 15236536 |
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| DOI: | 10.1016/j.bbmt.2008.11.010 |