Academic Journal
Clinical Syndrome Associated with Zolpidem Ingestion in Dogs: 33 Cases (January 1998‐July 2000)
| العنوان: | Clinical Syndrome Associated with Zolpidem Ingestion in Dogs: 33 Cases (January 1998‐July 2000) |
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| المؤلفون: | Richardson, Jill A., Gwaltney‐Brant, Sharon M., Albretsen, Jay C., Khan, Safdar A., Porter, Jessica A. |
| المصدر: | Journal of Veterinary Internal Medicine ; volume 16, issue 2, page 208-210 ; ISSN 0891-6640 1939-1676 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2002 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Zolpidem is a nonbenzodiazepine hypnotic of the imidazopyridine class that is used to treat insomnia in humans. Zolpidem binds selectively to the benzodiazepine omega‐1 receptor and increases the frequency of chloride channel opening, which results in inhibition of neuronal excitation. A retrospective study was conducted of zolpidem ingestion in dogs that were reported to the ASPCA Animal Poison Control Center (APCC) between January 1998 and July 2000. Data analysis included amount ingested, clinical effects, and time of onset of signs. Thirty‐three reports of zolpidem ingestion in dogs (ranging in age from 5 months to 16 years) were evaluated. Approximate ingested dosages ranged from 0.24 to 21 mg/kg. Clinical signs reported included ataxia (18 dogs; 54.5%), hyperactivity (10 dogs; 30.3%), vomiting (7 dogs; 21.2%), and lethargy (5 dogs; 15.2%), as well as panting, disorientation, nonspecific behavior disorder, and hypersalivation (4 dogs each sign; 12.1%). Other signs reported include tachycardia, tremors, apprehension, vocalization, hypersalivation, weakness, and hyperesthesia. In 85% percent of reports, clinical signs developed within 1 hour and usually resolved within 12 hours. Although central nervous system (CNS) depression is reported as a primary effect of zolpidem in humans and would also be expected in dogs, information obtained from this study indicates that some dogs may exhibit a paradoxical excitation reaction. This effect appears to vary among individual dogs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1939-1676.2002.tb02357.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1939-1676.2002.tb02357.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1939-1676.2002.tb02357.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1939-1676.2002.tb02357.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.3D1595BB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1939-1676.2002.tb02357.x |
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