Academic Journal
Evaluation of Anti-inflammatory, Anti-pyretic, Analgesic, and Hepatoprotective Properties of Terminalia macroptera
| العنوان: | Evaluation of Anti-inflammatory, Anti-pyretic, Analgesic, and Hepatoprotective Properties of Terminalia macroptera |
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| المؤلفون: | Haïdara, Mahamane, Dénou, Adama, Haddad, Mohamed, Camara, Aïssata, Traoré, Korotoumou, Aubouy, Agnès, Bourdy, Geneviève, Sanogo, Rokia |
| المساهمون: | Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Université des Sciences, des Techniques et des Technologies de Bamako (USTTB) |
| المصدر: | ISSN: 2509-9264 ; Planta Medica International Open ; https://hal.science/hal-03113936 ; Planta Medica International Open, 2020, 07 (02), pp.e58 - e67. ⟨10.1055/a-1142-7072⟩. |
| بيانات النشر: | HAL CCSD Thieme |
| سنة النشر: | 2020 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | Terminalia macroptera, Combretaceae, Improved traditional medicines/Médicaments Traditionnels Améliorés, medicinal plant antipyretic, anti-inflammatory, hepatoprotective, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology |
| الوصف: | International audience ; In Mali, improved traditional medicines [“Médicaments Traditionnels Améliorés”] are prepared from traditionally used medicinal plants. Recently, the Department of Traditional Medicine has identified Terminalia macroptera Guill. & Perr. (Combretaceae) as a potential candidate for an improved traditional medicine. T. macroptera is a West African medicinal plant used in Mali against various health disorders, with more than 30 different indications mentioned by traditional healers, including hepatitis, gonorrhea, fever, pain relief, and various infectious diseases (Helicobacter pylori-associated diseases). To date, validation of most of the biological activities of has been mainly carried out in vitro, except for antimalarial activities. In this study, the potential anti-inflammatory, antipyretic, analgesic, and hepatoprotective properties of T. macroptera were investigated in different murine models. Administration of T. macroptera ethanolic root and leaf extracts in rats significantly reduced pyrexia, pain, inflammation, and hepatic marker enzymes such as alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase in the different murine models used (p<0.05). A phytochemical screening of T. macroptera revealed the presence of tannins, flavonoids, saponins, anthracene derivatives, sterols, triterpenes, and sugars in both leaf and root extracts as the main phytochemical compounds. This was confirmed by qualitative analysis, liquid chromatography coupled with high-resolution mass spectrometry. T. macroptera extracts demonstrated interesting in vivo antipyretic, analgesic, anti-inflammatory, and hepatoprotective activities. Therefore, T. macroptera should be proposed and further evaluated as a potential improved traditional medicine for the treatment of liver-related disorders and for the relief of pain and fever.Key words |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-03113936; https://hal.science/hal-03113936; https://hal.science/hal-03113936/document; https://hal.science/hal-03113936/file/2020_PMIO.pdf%20.pdf |
| DOI: | 10.1055/a-1142-7072 |
| الاتاحة: | https://hal.science/hal-03113936 https://hal.science/hal-03113936/document https://hal.science/hal-03113936/file/2020_PMIO.pdf%20.pdf https://doi.org/10.1055/a-1142-7072 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.3CEDBE79 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1055/a-1142-7072 |
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